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Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
Mass spectrometry (MS) measurements are not inherently calibrated. Researchers use various calibration methods to assign meaning to arbitrary signal intensities and improve precision. Internal calibration (IC) methods use internal standards (IS) such as synthesized or recombinant proteins or peptide...
ORGANISM(S): Saccharomyces Cerevisiae 
2019-02-02 | PXD011297 | panorama
Mass spectrometry is a powerful tool for quantifying protein abundance in complex samples. Advances in sample preparation and the development of data independent acquisition (DIA) mass spectrometry approaches have increased the number of peptides and proteins measured per sample. However, methods to...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.
To seek effects of inflammatory status and 5-aminosalicylic acid (5-ASA, mesalazine) exposure ex vivo on mRNA levels within rectal mucosal biopsies from patients with ulcerative colitis. A total of 12 biopsies were analysed, 3 biological replicates in each of 4 categories (inflamed with or without 5...
ORGANISM(S): Homo sapiens 
Genome wide DNA methylation profiling of 4 human tissues of various ages: 83 samples of normal adjacent resected kidney tissue .The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Sentrix barcode provided for bat...
ORGANISM(S): Homo sapiens 
Genome wide DNA methylation profiling of 4 human tissues of various ages: 51 vastus lateralis samples.The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Sentrix barcode provided for batch normalization 500ng of ...
ORGANISM(S): Homo sapiens 
Genome wide DNA methylation profiling of 4 human tissues of various ages: 71 human buffy coat samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Sentrix barcode provided for batch correction Buffy coats...
ORGANISM(S): Homo sapiens 
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