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Transcriptomicscelecoxib-treated vs control breast tumours
Biopsies and surgical specimens were obtained from breast tumours treated and non-treated with celecoxib 400mg twice daily for 2 weeks
ORGANISM(S): Homo sapiens 
2013-03-28 | E-MTAB-566 | biostudies-arrayexpress
GenomicsOMRF SLEGEN GWAS Data from European-American Women with Lupus

"Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls,...

phs000202.v1.p1 | EGA
GenomicsInternational Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN)

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

phs000216.v1.p1 | EGA
TranscriptomicsTranscription profiling of skeletal muscle in TypeII diabetes patients to investigate mitochondrial dysfunction .
Skeletal muscle mitochondrial dysfunction is secondary to T2DM and can be improved by long-term regular exercise training Mitochondrial dysfunction has long been implicated to play a causative role in development of type 2 diabetes (T2DM). However, a growing number of recent studies provide data th...
ORGANISM(S): Homo sapiens 
2010-11-29 | E-GEOD-19420 | biostudies-arrayexpress
TranscriptomicsPreadipocytes of T2DM patients display an intrinsic gene expression profile of decreased differentiation capacity
Insulin resistance and Type 2 Diabetes Mellitus (T2DM) are associated with increased adipocyte size, altered secretory pattern and decreased differentiation of preadipocytes. To identify the underlying molecular processes in preadipocytes of T2DM patients that are a characteristic of the development...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15790 | biostudies-arrayexpress
TranscriptomicsOXPHOS complex I deficiency leads to transcriptional changes of the Nrf2-Keap1 pathway and selenoproteins.
Defective complex I (CI) is the most common type of oxidative phosphorylation (OXPHOS) disease in patients, with an incidence of 1 in 5,000 live births. Complex I deficiency can present in infancy or early adulthood and shows a wide variety of clinical manifestations, including Leigh syndrome, (card...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27041 | biostudies-arrayexpress
UnknownComparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257.
Not available
S-EPMC4660025 | biostudies-literature
UnknownIncisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART).
Not available
S-EPMC10364691 | biostudies-literature
TranscriptomicsExpression data from POLG1 patients and control subjects muscle
Pathogenic mutations in the catalytic DNA polymerase gamma (POLG1) gene result in the accumulation of mtDNA mutations, deletions and/or decrease of mtDNA copy number. These features interfere with proper functioning of the electron transport chain, mostly affecting metabolically active tissues such ...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-18715 | biostudies-arrayexpress
UnknownQuality of anticoagulation control in preventing adverse events in patients with heart failure in sinus rhythm: Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial substudy.
Not available
S-EPMC4439299 | biostudies-literature
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