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TranscriptomicsRNA-seq data of acute leukemias of ambiguous lineage (ALAL)
We generated RNA-seq data of 30 cases of acute leukemia of ambiguous lineage (ALAL), including both bilineal and biphenotypic patients, in order to develop methods to improve the diagnosis of this disease. First, we used an in-house pipeline to comprehensively detect genetic lesions in RNA-sequencin...
ORGANISM(S): Homo sapiens 
2025-05-16 | E-MTAB-15145 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of leukemias of ambiguous lineage
Classifying leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia using microRNA expression profiling
ORGANISM(S): Homo sapiens 
2013-05-07 | E-MTAB-1459 | biostudies-arrayexpress
GenomicsDynamic transcriptomic tracking directs the treatment for acute leukemia of ambiguous lineage
Dynamic transcriptomic tracking directs the treatment for acute leukemia of ambiguous lineage
PRJNA495930 | ENA
ProteomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia
ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but the mechanistic role of ZNF384 FO in leukemogenesis and lineage ambiguity is poorly understood. Here, using viral expression in mouse and human hematopoietic stem and progenitor cells (HSPCs) and a Ep300-Z...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD028481 | Pride
Znf384 Stem cell Leukemia Fusion oncoprotein Lineage ambiguous Mixed phenotype 
UnknownMixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Not available
S-EPMC7489437 | biostudies-literature
UnknownEnhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Not available
S-EPMC8563395 | biostudies-literature
UnknownEnrichment of Double RUNX1 Mutations in Acute Leukemias of Ambiguous Lineage.
Not available
S-EPMC8444989 | biostudies-literature
UnknownVenetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia.
Not available
S-EPMC12377505 | biostudies-literature
GenomicsBCL11B enhancer hijacking defines a subtype of lineage ambiguous stem cell leukemia
BCL11B enhancer hijacking defines a subtype of lineage ambiguous stem cell leukemia
PRJNA693549 | ENA
TranscriptomicsExpression data from Tcf1 deficient and Tcf1 wildtype cultured bone marrow lymphoid primed progenitors after four days on Notch ligand expressing stroma (OP9-DL4).
Tcf1 is necessary for optimal T lineage development. Tcf1 deficient progenitors fail to initiate the T lineage program in vitro and development is severely defective in vivo. We used microarrays to assess the overal global gene expression differences from Tcf1 wildtype and deficient lymphoid biased ...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-26559 | biostudies-arrayexpress
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