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MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsHuman hematopoietic stem cell expansion through modulation of lineage-associated gene expression programs
Hematopoietic stem cells (HSCs) must balance self-renewal and lineage differentiation to regenerate the hematopoietic system throughout life. HSCs exhibit lineage-associated gene expression that keeps them responsive to demands of mature blood production. However, it is not known whether this proces...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-45486 | biostudies-arrayexpress
ProteomicsDppa2/4 target chromatin bivalency enabling multi-lineage commitment
Epigenetic priming factors establish a permissive epigenetic landscape which is not required until a later developmental or physiological time point, temporally uncoupling the presence of these factors with their phenotypic effects. One classic example of epigenetic priming is in the context of biva...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD014981 | Pride
Qplex rime Epigenetic priming Compass Bivalency Development Trithorax 
GenomicsEpigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment
Epigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment
PRJNA560249 | ENA
GenomicsExtensive epigenetic priming in multipotent progenitors precedes lineage specification in B-lymphocyte development.
Extensive epigenetic priming in multipotent progenitors precedes lineage specification in B-lymphocyte development.
PRJNA683602 | ENA
UnknownPriming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment.
Not available
S-EPMC3246047 | biostudies-literature
GenomicsStage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run]
Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run]
PRJNA1267101 | ENA
TranscriptomicsSingle-cell RNA-seq of bone marrow-derived mesenchymal stem cells reveals unique profiles of lineage priming
The plasticity and immunomodulatory capacity of mesenchymal stem cells (MSCs) have spurred clinical use in recent years. However, clinical outcomes vary and many ascribe inconsistency to the tissue source of MSCs. Yet unconsidered is the extent of heterogeneity of individual MSCs from a given tiss...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-70930 | biostudies-arrayexpress
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