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ProteomicsInner membrane proteome of E. coli Min mutant
In bacteria, proteins of the MinD/ParA superfamily are reported to partition DNA and protein complexes to designate subcellular location. Among them, the E. coli Min system is a prominent example to demonstrate that the protein function is spatially regulated by the dynamic subcellular localization ...
ORGANISM(S): Escherichia coli 
2016-02-23 | PXD002548 | Pride
Cell division The min system Itraq E. coli Membrane 
MetabolomicsMetabolome analysis reveal key regulatory pathways of feed conversion efficiency of oriental river prawn Macrobrachium nipponense

A total of 445 and 247 differently expressed metabolites (DEMs) were identified in the hepatopancreas and muscle. In addition, 11 KEGG pathways, which mainly include lysine biosynthesis, lysine degradation, aminoacyl-tRNA biosynthesis and purine metabolism, were sign...

2023-02-28 | MTBLS6663 | MetaboLights
TranscriptomicsMicroRNA expression profiling in GC-2 cells following 50 Hz ELF-EMF
Aberrant miRNA expression has been related to the development of human germ cell tumors, but little is known about effect of ELF-EMFs on miRNA expression. ELF-EMFs may epigenetically modify cells, which may account for the adverse effects of ELF-EMFs on the male reproductive system. To identify miRN...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-71147 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of grape (Vitis vinifera L.) leaves exposed to ultraviolet C radiation
Solar ultraviolet C（UV-C）radiation reaching the Earth’s surface is little due to the filtering effects of the stratospheric ozone layer. At present, artificial UV-C irradiation is utilized for different biological processes. Grape is a major fruit crop around the world. Research has shown that UV-C ...
ORGANISM(S): Vitis vinifera 
2014-11-15 | E-GEOD-62315 | biostudies-arrayexpress
Transcriptomicsshld1 effect on 3T3 cell
NIH3T3 cells were cultured in medium containing 1 uM, 100 nM, 10 nM and 0 nM (serve as control) shld1 for 24 hours. Three independent cultures were obtained for each drug concentration. Total RNA from experimental samples were extracted using RNeasy Kit (Qiagen). Mouse RNA pooled from 11 cell line...
ORGANISM(S): Mus musculus 
2007-09-27 | E-GEOD-5916 | biostudies-arrayexpress
TranscriptomicsIdentification of rapidly-induced genes in the peanut (Arachis hypogaea) response to water deficit and abscisic acid
Purpose: to screen the candidate genes involved in the peanut drought stress response, we conducted global transcriptome analysis of peanut plants challenged with water deficit and ABA, using the Illumina HiSeq2000 sequencing platform. Methods: a sequences library of Yueyou7 were constructed at firs...
ORGANISM(S): Arachis hypogaea 
2014-05-13 | E-GEOD-56439 | biostudies-arrayexpress
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
UnknownBaicalin alleviates H<sub>2</sub>O<sub>2</sub>-induced oxidative stress injury in human umbilical vein endothelial cells by regulating the TNF-[Formula: see text]-mediated MAPK/ERK1/2/MPO pathway.
Not available
S-EPMC12508144 | biostudies-literature
TranscriptomicsDisrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43 (CLIP)
Cross-linking and immunoprecipitation coupled with high-throughput sequencing was used to identify binding sites within 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein which when mutated causes Amyotrophic Lateral Sclerosis (ALS). Use of massively parallel sequencing and spli...
ORGANISM(S): Mus musculus 
2011-03-03 | E-GEOD-27201 | biostudies-arrayexpress
ProteomicsBTN2A1 Targeting Reprograms M2-like Macrophages and TAMs via SYK and MAPK Signaling
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across diverse cancer types. We developed anti-BTN2A1 monoclonal antibod...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD055262 | Pride
Lc-msms Ap-ms Butyrophilin (btn)2a1 Reprogramming Mapk Immunosuppressive m2-like Syk Cancer 
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