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TranscriptomicsChanges in bone marrow resident monocyte gene expression upon induction of ischemia
There is considerable interest in the potential of cell-based approaches to mediate therapeutic angiogenesis for acute and chronic vascular syndromes. Using a mouse model of HLI, we showed previously that adoptive transfer of a small number of donor monocytes enhanced revascularization significantly...
ORGANISM(S): Mus musculus 
2010-04-26 | E-GEOD-21509 | biostudies-arrayexpress
TranscriptomicsMurine Bone Marrow Stromal Cell Response to Granulocyte Colony-Stimulating Factor
Neutrophil homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal for neutrophils in the bone marrow through activation of its receptor CXCR4. Her...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-22925 | biostudies-arrayexpress
TranscriptomicsCXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
Hematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation, and trafficking. Endosteal osteoblasts and perivascular stromal cells including endothelial cells3, CXCL12-abundant reticular (CAR) cells, leptin-...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43613 | biostudies-arrayexpress
TranscriptomicsHematopoietic stem cells from mice treated with G-CSF or saline alone for 36 hours
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte-colony stimulating factor (G-CSF) is often induced with infection and plays a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show tha...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-55093 | biostudies-arrayexpress
ProteomicsIMProv: A Resource for Crosslink-Driven Structure Modeling that Accommodates Protein Dynamics
Crosslinking and hydrogren-deuterium exchange data of Polycomb Repressive Complex 2 used for integrative modelling.
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD022861 | Pride
Crosslinking mass spectrometry Software Integrative modelling 
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
Mass spectrometry results from TurboID experiments using constructs expressing TurboID only, NPM1wt-Turbo ID (N- and C-terminal fusions) and NPMc-Turbo ID fusions (N- and C-terminal fusions) transduced in primary mouse hematopoietic stem/progenitor cells from lineage-depleted mouse bone marrow.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089028 | MassIVE
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
A deep-scale proteome and phosphoproteome database from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls including 3 lineage-depleted and 3 CD34+ selected bone marrows.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-07 | MSV000089012 | MassIVE
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
Deep-scale proteome and phosphoproteome protocol benchmark.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-10 | MSV000089035 | MassIVE
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
Label-free quantitation dataset from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls including 3 lineage-depleted and 3 CD34+ selected bone marrows.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089029 | MassIVE
GenomicsWhole-Genome Sequencing of Acute Myeloid Leukemia

We used massively parallel sequencing technology to sequence the genomic DNA of tumor cells (leukemic bone marrow) and normal cells (skin biopsy) obtained from patients with Acute Myeloid Leukemia (AML). Patients had either de novo AML (AML with no prior diagnosis of a hematologic disease or expo...

phs000159.v4.p2 | EGA
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