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UnknownThe trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection.
Not available
S-EPMC5892718 | biostudies-literature
MetabolomicsAspSnFR: A Genetically-Encoded Biosensor for Real-Time Monitoring of Aspartate in Live Cells

Aspartate is crucial for nucleotide synthesis, ammonia detoxification and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate concentrations in real time and in live cells. We intr...

2024-08-27 | MTBLS10035 | MetaboLights
ProteomicsThe IMiD receptor CRBN determines quality control of transmembrane proteins
The complex architecture of transmembrane proteins requires quality control (QC) for folding and membrane positioning, a prerequisite for cellular homoeostasis and intercellular communication. However, it has remained unclear whether transmembrane proteins-specific QC hubs exist. Here we specify Cer...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD018244 | Pride
Imids Chaperones Membrane proteins Lumos Human Multiple myeloma 
UnknownNFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway.
Not available
S-EPMC5514916 | biostudies-literature
UnknownHemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.
Not available
S-EPMC6238743 | biostudies-literature
TranscriptomicsEffects of microcystis on Daphnia pulex
Although cyanobacteria produce a wide range of natural toxins that impact aquatic organisms, food webs and water quality, the mechanisms of toxicity are still insufficiently understood. Here, we implemented a whole-genome expression microarray to identify pathways, gene networks and paralogous gene ...
ORGANISM(S): Daphnia pulex 
2012-07-26 | E-GEOD-36635 | biostudies-arrayexpress
GenomicsAnalysis of translatome, truncating mutations, lncRNA, circRNA and microproteins of 80 human DCM cases and controls
The regulation of gene expression in healthy and diseased human tissues is incompletely understood and has primarily been studied on the transcriptional level. Here, we quantify the impact of translation on gene expression and annotate novel translational events in 80 human hearts. These include 65 ...
EGAS00001003263 | EGA
TranscriptomicsExpression data from Sh2b3 Knock-out NOTCH1-induced leukemias
To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full l...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-44025 | biostudies-arrayexpress
ProteomicsQuantitative proteomic study of two cervical cancer cell lines upon re-expression of Galectin 7
Galectin-7 expression was found to be strongly reduced in cervical cancer cell lines. The same tumor cell lines in which Galectin-7 was ectopically expressed exhibited significant decrease in their tumorigenic capacity in vitro and in vivo. The proteomic changes in the cervical cancer cell lines HeL...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080855 | MassIVE
ModelsSignaling Pathway for Butanol Production in Clostridium beijerinckii NRRL B-598
Not available
36604 | Cell Collective
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