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ProteomicsA quantitative map of beta-lactone induced virulence regulation
Beta-lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus alpha-toxin production a link between ...
ORGANISM(S): Staphylococcus aureus 
2017-02-08 | PXD004680 | Pride
Proteomics Chemical knockout S. aureus clpp Antivirulence Activity-based protein profiling 
UnknownPopulation structure, genetic diversity and pathotypes of Streptococcus suis isolated during the last 13 years from diseased pigs in Switzerland.
Not available
S-EPMC7346511 | biostudies-literature
UnknownComplete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities.
Not available
S-EPMC9169379 | biostudies-literature
MetabolomicsNatural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data
The 19 parent lines of the Arabidopsis thaliana MAGIC collection show significant differences in their root exudate profiles. Changes in metabolism were analyzed by ultra-performance liquid chromatography coupled to electrospray ionization quadrupole time–of–flight mass spectrometry (UPLC-ESI-QTOF-M...
2017-02-03 | MTBLS160 | MetaboLights
ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
UnknownDeep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
Not available
S-EPMC5886112 | biostudies-literature
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
ProteomicsHelicobacter pylori gamma-glutamyltransferase relates to proteomic adaptations important for colonization
Helicobacter pylori γ-glutamyltransferase (gGT) is a conserved virulence factor promoting bacterial colonization and immune tolerance. Although some studies addressed potential mechanisms explaining its function, the supportive role of gGT for in-vivo colonization remains unclear. In addition, it is...
ORGANISM(S): Helicobacter pylori PMSS1 Helicobacter pylori G27 
2025-04-08 | PXD050334 | Pride
In-vivo mouse infection Full proteome Helicobacter pylori Secretome Lc-ms/ms 
TranscriptomicsIron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype
We found histological evidence for increased abundance of iron accumulating cells in association with fibrotic lung, kidney, and heart diseases in mice and humans. We showed that inducing iron accumulation by intratracheal iron delivery in mice is a potent inducer of inflammation, cellular senescenc...
ORGANISM(S): Mus musculus 
2023-08-18 | E-MTAB-13032 | biostudies-arrayexpress
TranscriptomicsEvidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Cohesin is a multisubunit complex that mediates sister-chromatid cohesion. Its Smc1 and Smc3 subunits possess ABC-like ATPases at one end of 50 nm long coiled coils. At the other ends are pseudosymmetrical hinge domains that interact to create V-shaped Smc1/Smc3 heterodimers. N- and C-terminal domai...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-4827 | biostudies-arrayexpress
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