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GenomicsMapping of somatic linker histone H1 variants in T47D-MTVL cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49334 | biostudies-arrayexpress
GenomicsGenomic distribution of linker histone varinat H1T
We report genome-wide distribution of germ cell-specific linker histone variant H1T in cancer cell line AGS, MDA-MB-231, and mouse embryonic stem cells (mESCs). We found that H1T expressed not only testis but also non-germ cells such as cancer cells and pluripotent stem cells and showed the biased d...
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-75287 | biostudies-arrayexpress
TranscriptomicsMapping of somatic linker histone H1 variants in T47D-MTVL and HeLa cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49333 | biostudies-arrayexpress
TranscriptomicsHistone H1 binding is restricted by histone variant H3.3 (DamID)
Linker histones are involved in the formation of higher-order chromatin structure. Although linker histones have been implicated in the regulation of specific genes, it still remains unclear what their principal binding determinants are and how their repressive function in vitro can be reconciled wi...
ORGANISM(S): Drosophila melanogaster 
2010-06-21 | E-GEOD-16883 | biostudies-arrayexpress
ProteomicsIdentification and analysis of phosphorylation within Xenopus laevis linker histone H1.0
As a key structural component of the chromatin of higher eukaryotes, linker histones (H1s) are involved in stabilizing the folding of extended nucleosome arrays into higher-order chromatin structures and function as a gene-specific regulators of transcription in vivo. The H1 C-terminal domain (CTD) ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-12 | PXD032292 | Pride
Identification and analysis of phosphorylation within xenopus laevis linker histone h1.0 
TranscriptomicsLinker histone H1.2 establishes chromatin comapction and gene silencing through recognition of H3K27me3
Linker histone H1 is a protein component of chromatin and has been linked to chromatin compaction and global gene silencing.It has been sugegsted that H1 plays a significant role, regulating a relatively small number of genes. Here we show that H1.2- a variant of H1 subtype is recruited to chromati...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-68050 | biostudies-arrayexpress
ProteomicsProtein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker
To identify components of the U7 snRNP, we used cleavage-resistant histone pre-mRNA containing biotin and a photo-sensitive linker and purify processing complexes from Drosophila and mouse nuclear extracts.
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2018-03-08 | PXD008917 | Pride
Flash  lsm11 Histone pre-mrna Photo-cleavable linker 3’ end processing U7 snrnp  slbp 
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 [Affymetrix Expression]
Indicated cells were subjected to RNAi against linker histone H1, Nautilus (control), or GFP (control). RNA was isolated and subjected to Affymetrix GeneChIP Drosophila Genome 2.0 arrays RNA was compared from cells treated with RNAi against control (Nautilus in the case of salivary glands or GFP in...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44398 | biostudies-arrayexpress
TranscriptomicsHistone H1 binding is restricted by histone variant H3.3 (Nucleosome)
Linker histones are involved in the formation of higher-order chromatin structure. Although linker histones have been implicated in the regulation of specific genes, it still remains unclear what their principal binding determinants are and how their repressive function in vitro can be reconciled wi...
ORGANISM(S): Drosophila melanogaster 
2010-06-23 | E-GEOD-16882 | biostudies-arrayexpress
TranscriptomicsHistone H1 binding is restricted by histone variant H3.3 (Expression)
Linker histones are involved in the formation of higher-order chromatin structure. Although linker histones have been implicated in the regulation of specific genes, it still remains unclear what their principal binding determinants are and how their repressive function in vitro can be reconciled wi...
ORGANISM(S): Drosophila melanogaster 
2010-06-21 | E-GEOD-16884 | biostudies-arrayexpress
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