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ProteomicsLip-SMap analysis of traumatic acid in HT-22
To explore potential targets of TA, LiP-SMap assay was used to identify the cellular proteins which could directly binding to TA. HT-22 cell lysates (three biological replicates for TA treatment) were incubated with TA or DMSO (vehicle), followed by limited proteolytic hydrolysis with proteases K an...
ORGANISM(S): Mus Musculus 
2023-12-01 | PXD047489 |
ProteomicsA map of protein-metabolite interactions reveals principles of chemical communication
Application of a novel mass spectrometry-based high-throughput workflow (LiP-SMap) and data resource based on limited proteolysis (LiP) of complex samples. Proteome-wide limited proteolysis sites were obtained in different conditions to infer ligand-induced and protein-protein interaction induced co...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2018-01-04 | PXD006543 | Pride
Small molecules Limited proteolysis Lip-smap Dia-ms E.coli 
ProteomicsRepurposing cinacalcet suppresses multi-drug resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR
Multi-drug resistant Staphylococcus aureus (S. aureus) infections continously threaten public health. The rapid escalation in morbidity and mortality rates associated with methicillin-resistant S. aureus (MRSA) infections necessitates the urgent development of novel antimicrobial agents. Our study r...
ORGANISM(S): Staphylococcus aureus 
2024-02-07 | PXD041266 | Pride
Mutidrug-resistance  s. aureus  cinacalcet  icar  membrane 
ProteomicsMetabolite interactions in the bacterial Calvin cycle and implications for flux regulation
Metabolite-level regulation of enzyme activity is important for microbes to cope with environmental shifts. Knowledge of such regulations can also guide strain engineering to improve industrial phenotypes. Recently developed chemoproteomics workflows allow for genome-wide detection of metabolite-pro...
ORGANISM(S): Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) Hydrogenophaga pseudoflava Synechocystis sp. (strain PCC 6803 / Kazusa) Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2023-08-23 | PXD044412 | Pride
Cupriavidus necator Cyanobacteria Prosit Synechococcus sp. pcc7942 Interaction proteomics Encyclopedia Hydrogenophaga pseudoflava Lip-smap Carbon fixation Synechocystis sp. pcc6803 Ralstonia eutropha 
ProteomicsThe glycolytic signaling metabolite fructose-1,6-bisphosphate shapes cell adhesion and protrusion
Cellular adhesion to the extracellular matrix is essential for morphogenesis, tissue integrity and survival signaling. The best understood adhesion structures are focal adhesions. Inspite of their importance, our knowledge of upstream regulatory factors that integrate focal adhesion assembly with ot...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD043853 | Pride
Cytoskeleton Metabolism 
UnknownMetabolite interactions in the bacterial Calvin cycle and implications for flux regulation.
Not available
S-EPMC10507043 | biostudies-literature
TranscriptomicsTranscriptomic analysis of Platycodin D (PD)-improved idiopathic pulmonary fibrosis (IPF) mice
This study focuses on the role of PD, a natural compound derived from traditional Chinese medicine, in the prevention and treatment of IPF, a disease in which pulmonary fibroblast-to-myofibroblast transdifferentiation is a key pathogenic driver. By employing both in vivo and in vitro IPF models, com...
ORGANISM(S): Mus musculus 
2026-02-01 | GSE317792 | GEO
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
TranscriptomicsAdipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing
Circulating trimethylamine N-oxide (TMAO) participates in the pathogenesis of cardio-metabolic diseases, with hepatic flavin-containing monooxygenase 3 (FMO3) originally regarded as the primary source of TMAO production. Here, we demonstrate that white adipose tissue (WAT) expressed FMO3 and its der...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE294785 | GEO
UnknownThe tryptophan metabolite 3-hydroxyanthranilic acid alleviates hyperoxia-induced bronchopulmonary dysplasia via inhibiting ferroptosis.
Not available
S-EPMC11981817 | biostudies-literature
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