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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsLysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

Lysosomes are key cellular organelles that metabolize extra- and intra-cellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to ...

2022-05-06 | MTBLS4654 | MetaboLights
MetabolomicsA thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice
Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we showed that Serinc2, a BD susceptibility gene encoding a L-serine transporter that regulates membrane lipid synthes...
2026-07-06 | MTBLS14954 | MetaboLights
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
MetabolomicsA gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI

A gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI


Probiotic L. reuteri attenuates neuroinflammation and anxiety symptoms through gut-brain axis via a novel metabolite 20-HETE in blast-induced traumatic brain injury

2026-07-17 | MTBLS15072 | MetaboLights
MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-31 | MTBLS14191 | MetaboLights
MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-29 | MTBLS14183 | MetaboLights
MetabolomicsDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis
Aims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the g...
2026-05-25 | MTBLS14575 | MetaboLights
MetabolomicsGut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling

This study investigated age-associated changes in the gut-muscle axis and their potential contribution to meat quality in Tan sheep (Ovis aries). Twelve Tan sheep were divided into two age groups, including six 3-month-old animals (T3) and six 6-month-old animals (T6). Untargeted LC-MS metabolomi...

2026-09-03 | MTBLS15419 | MetaboLights
MetabolomicsUntargeted lipid profiling following mTOR inhibition

The mechanistic target of rapamycin (mTOR) is pivotal in programming cellular lipid homeostasis for the structural and functional integrity of cells. Dysregulation of mTOR and consequent altered lipid metabolism are common features in various diseases, including cancers, making mTOR signaling a p...

2025-09-20 | MTBLS12837 | MetaboLights
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