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GenomicsmTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
mTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
PRJNA854056 | ENA
ProteomicsIdentification of molecular machinery mediating ER to lipid droplet protein targeting
Lipid droplets (LDs) are organelles that store lipids and contain important metabolic proteins at their surfaces. The pathway for membrane-embedded hydrophobic proteins to reach the LD surface from the ER is largely unknown. Here, we find that many proteins, including key lipid synthesis and degrada...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-27 | PXD027283 | Pride
Endoplasmic reticulum Protein trafficking Membrane fusion Protein targeting Lipid droplet 
TranscriptomicsDysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in t...
ORGANISM(S): Mus musculus 
2014-10-06 | E-GEOD-54418 | biostudies-arrayexpress
TranscriptomicsmTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A
FAM120A as a transcriptional co-activator that couples transcription and splicing of lipid synthesis enzymes downstream of mTORC1-SRPK2 signaling. Mechanistically, the mTORC1-activated SRPK2 phosphorylates a splicing factor SRSF1, enhancing its binding to FAM120A. FAM120A directly interacts with a l...
ORGANISM(S): Homo sapiens 
2022-07-02 | GSE207172 | GEO
ProteomicsDeoxynivalenol and human epidermal cells: proteomic profiling indicates alterations of cell membrane integrity and barrier function
The possibility to combine untargeted proteomic workflows to more classical experimental approaches is continuously opening new insights in all branches of biological sciences. Deoxynivalenol (vomitoxin, DON) is a secondary metabolite produced by Fusarium spp. fungi and it is one of the most recurre...
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD013613 | Pride
Lipid synthesis machinery Vomitoxin)  human epidermal keratinocytes (hekn) Deoxynivalenol (don 
ProteomicsMultiplexed proteomics of a cellular transition from G0 to cell cycle in response to IL-3 activation
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation of these metabolic changes have not been properly e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-21 | MSV000081179 | MassIVE
UnknownEnteroviruses harness the cellular endocytic machinery to remodel the host cell cholesterol landscape for effective viral replication.
Not available
S-EPMC3802520 | biostudies-literature
ProteomicsGené organ engagement in lipid metabolism revealed by a combined transcriptomic and proteomic approach
Gené organ (GO) is an exclusive apparatus of female ticks that secretes a protective wax coat onto the egg surface. This wax coat makes eggs more viable in the environment due to its waterproof, stickiness and antimicrobial proprieties. In this work, a combined transcriptomic and proteomic approach ...
ORGANISM(S): Rhipicephalus microplus 
2022-03-01 | PXD011223 | Pride
Transcriptome Gené organ Lipid gland Tick Egg wax Proteome 
TranscriptomicsThe translational landscape of mTOR signaling steers cancer initiation and metastasis
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Employing riboso...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35469 | biostudies-arrayexpress
UnknownReconstitution of prenyltransferase activity on nanodiscs by components of the rubber synthesis machinery of the Para rubber tree and guayule.
Not available
S-EPMC8904820 | biostudies-literature
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