Sort   by:  
 Page size 
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
MetabolomicsAn overexpression of lipoprotein lipase leads to an alteration in the skeletal muscle metabolome in transgenic rabbits
Not available
ORGANISM(S): Oryctolagus cuniculus 
ST001684 | MetabolomicsWorkbench
TranscriptomicsThe ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein Lipase
Sel1L is an adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), but its physiological role in a cell-type-specific manner remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-56918 | biostudies-arrayexpress
TranscriptomicsLiver gene expression profiling of lipoprotein lipase heterozygous knockout mice
Lipoprotein lipase (Lpl) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of lipoprotein lipase heterozygous knockout mice (Lpl+/-) and their littermat...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11991 | biostudies-arrayexpress
TranscriptomicsLipoprotein lipase in chronic lymphocytic leukemia - strong biomarker with lack of functional significance
LPL co-deregulated genes after LPL specific siRNA knock-down In chronic lymphocytic leukemia (CLL), lipoprotein lipase (LPL) mRNA overexpression is an established poor prognostic marker, its function, however, is poorly understood. Measuring extracellular LPL enzymatic activity and protein, we found...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-44247 | biostudies-arrayexpress
ProteomicsThe response to fasting and refeeding reveals functional regulation of lipoprotein lipase proteoforms
Lipoprotein lipase (LPL) is responsible for the intravascular catabolism of triglyceride-rich lipoproteins and plays a central role in whole-body energy balance and lipid homeostasis. As such, LPL is subject to tissue-specific regulation in different physiological conditions, but the mechanisms of t...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2024-01-26 | PXD043704 | Pride
Lipoprotein lipase Lipid metabolism Proteoform Tissue-specific regulation 
TranscriptomicsLiver gene expression profiling of lipoprotein lipase heterozygous knockout mice
Lipoprotein lipase (Lpl) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of lipoprotein lipase heterozygous knockout mice (Lpl+/-) and their littermate...
ORGANISM(S): Mus musculus 
2009-03-08 | GSE11991 | GEO
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human macrophages exposed to lipoprotein lipase hydrolysis products
Lipoprotein lipase (LPL) is an extracellular lipase that preferentially hydrolyses triglycerides in triglyceride-rich lipoproteins within the circulation. LPL expression in macrophages contributes to atherosclerosis. In addition, the hydrolysis products liberated from lipoprotein lipids by LPL cause...
ORGANISM(S): Homo sapiens 
2017-02-15 | GSE84791 | GEO
GenomicsLipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure
Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure
PRJNA647913 | ENA
Sort   by:  
 Page size