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UnknownCRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.
Not available
S-EPMC6697986 | biostudies-literature
TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
TranscriptomicsWidespread N6-methyladenosine-dependent RNA Structural Switches Regulate RNA-Protein Interactions
We show that N6-methyladenosine (m6A), the most abundant internal modification in mRNA/lncRNA with still poorly characterized function, alters RNA structure to facilitate the access of RBM for heterogeneous nuclear ribonucleoprotein C (hnRNP C). We term this mechanism m6A-switch. Through combining P...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-56010 | biostudies-arrayexpress
ProteomicsProteome Analysis of Avian Metapneumovirus C Type infected Vero cells by iTRAQ coupled with LC-MS
To date, no study has been carried out to assess the protein profiles of aMPV/C-infected cells. In the present study, iTRAQ combined with LC-MS/MS was used to reveal the global proteomic changes occurring in Vero cells in response to aMPV/C infection for the first time and to help understand the mol...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2020-04-03 | PXD017827 | Pride
Vero cells Lc-ms Ampv/c 
TranscriptomicsHigh resolution mapping of DNA replication origins in human genome
Because of the lack of information, regulation of DNA replication initiation in mammals is still poorly understood. In order to identify general rules, we have mapped replication origins along 1% of the human genome in HeLa cells. We found large gene-poor regions lacking origin and G+C rich regions ...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-10217 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and C/EBPbeta deficient mice during a partial hepatectomy time series to identify transcriptional targets of C/EBPbeta
The aim of this experiment was to use microarray analysis to compare the response of wild type (WT) and C/EBPbeta deficient (KO) mice during a partial hepatectomy time course in hopes of identifying transcriptional targets of C/EBPbeta. In addition, the WT time course alone was examined to analyze m...
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-16 | biostudies-arrayexpress
TranscriptomicsSupernatants derived from chemotherapy-treated tumours can modify angiogenesis.
The human lung cancer cell line A549 was cultured in media alone, with cyclophosphamide (CPM) or oxaliplatin (OXP) for 72 hours. The exhausted culture media were aspirated and the microvesicular fraction was harvested by sequential ultracentrifugation. RNA was then isolated from microvesicles by Tr...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-TABM-1201 | biostudies-arrayexpress
TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
MetabolomicsComparative analysis of proteomic and metabolomic profiles of different species of Paris

An extract prepared from species of Paris is the most widely consumed herbal product in China. The genus Paris includes a variety of genotypes with different medicinal component contents but only two are defined as official sources. Closely related species have different medicinal properties beca...

2020-01-13 | MTBLS779 | MetaboLights
TranscriptomicsTranscription profiling of in vivo-derived CMS4-met cells and the in vitro-derived CMS4.sel cells using CMS4 cells as a reference sample
The CMS4 sarcoma, kindly provided by A. DeLeo (University of Pittsburgh, Pittsburgh, PA), is a solid tumor of BALB/c (H-2d) origin, which grows aggressively in naive, syngeneic hosts following a s.c. transplant. Although the parental tumor cell line forms few metastatic foci in the lungs following i...
ORGANISM(S): Mus musculus 
2005-05-08 | E-MEXP-286 | biostudies-arrayexpress
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