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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
ProteomicsPhosphoproteomic analysis reveals the effects of sleep deprivation on the hippocampus of mice
Sleep deprivation has a significant effect on the level of protein phosphorylation modification in the hippocampus of mice.
ORGANISM(S): Mus Musculus 
2022-06-29 | PXD034972 |
UnknownDapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial.
Not available
S-EPMC12863589 | biostudies-literature
ProteomicsPACTS-assisted thermal proteome profiling identifies peptide-interacting proteins
The interaction between peptide ligands and protein receptors induced significant abundance changes of the target proteins, which was a signature to indicate the interaction and provide complementary information for the current thermal proteome profiling (TPP) technique
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031246 |
UnknownCarbon sequestration potential of tree planting in China.
Not available
S-EPMC11437143 | biostudies-literature
UnknownSTAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation
Not available
S-SCDT-EMBOJ-2018-99595 | biostudies-other
ProteomicsThe human pathobiont Malassezia furfur secreted protease MfSAP1 regulates cell dispersal and exacerbates skin inflammation
Malassezia forms the dominant eukaryotic microbial community on the human skin. The Malassezia genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and lipid metabolism which alter the external cutaneous environment. The exact role of most Malassezia secreted enzymes, inc...
ORGANISM(S): Cellular Organisms 
2022-11-11 | PXD033336 | JPOST Repository
ProteomicsAML cell line THP-1 shControl VS THP-1 shPSMB10
In the THP-1 cell line, knockdown of PSMB10 expression was performed using lentivirus, with a control group set up.
ORGANISM(S): Homo Sapiens 
2024-12-10 | PXD058714 |
ProteomicsIntegrative proteomics and precision N-glycoproteomics analyses of rheumatoid arthritis synovia reveal immune-associated glycopeptides
The precision glycoproteome in the synovium and its clinical significance are completely unknown. We performed precision N-glycoproteomics analysis of RA and OA synovial tissues, and identified many immune-associated N-glycopetides in this study for the first time, providing new insights into the me...
ORGANISM(S): Homo Sapiens 
2023-03-10 | PXD037581 |
ProteomicsIdentifying the patients with rapid progression from hormone-sensitive to castration-resistant prostate cancer
We collected 78 biopsies and analyzed the proteomic expression by pressure cycling technology and Pulsed data-independent acquisition (PCT-PulseDIA) pipeline. Next, we explore the differentially expressed proteins (DEPs) in the discovery set (n=16) which contains short (S, n=8)- and long (L, n=8)- t...
ORGANISM(S): Homo Sapiens 
2022-11-04 | PXD037951 |
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