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TranscriptomicsThe effects of naltrexone on gene expression in HCT116 colorectal cancer cell line
A number of reports have identified a putative anticancer role for naltrexone when used at doses lower than those conventionally administered. In particular, it has been shown that these low doses of naltrexone are able to suppress tumour growth. A definitive mechanism of action has yet to be establ...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-MTAB-4454 | biostudies-arrayexpress
UnknownComplete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.
Not available
S-EPMC4872006 | biostudies-literature
TranscriptomicsThe gene expression profile of dendritic cells can be used as a predictor of function.
The human lung cancer cell line A549 was cultured in media alone, with cyclophosphamide (CPM), oxaliplatin (OXP) or DMSO alone for 72 hours. The exhausted culture media were aspirated and stored at -20C. Peripheral blood mononuclear cells (PBMCs) were isolated from four pathologically healthy dono...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-MTAB-389 | biostudies-arrayexpress
TranscriptomicsSupernatants derived from chemotherapy-treated tumours can modify angiogenesis.
The human lung cancer cell line A549 was cultured in media alone, with cyclophosphamide (CPM) or oxaliplatin (OXP) for 72 hours. The exhausted culture media were aspirated and the microvesicular fraction was harvested by sequential ultracentrifugation. RNA was then isolated from microvesicles by Tr...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-TABM-1201 | biostudies-arrayexpress
MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
MetabolomicsMetabolomic and Metataxonomic Fingerprinting of Human Milk Suggests Compositional Stability over a Natural Term of Breastfeeding to 24 Months
Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in collaboration with the 'Parenting Science Gang' citizen science group evaluated the metabolite and bacterial composition of human milk from 62 ...
2022-02-11 | MTBLS1370 | MetaboLights
UnknownAntepartum sleep quality, mental status, and postpartum depressive symptoms: a mediation analysis.
Not available
S-EPMC9344627 | biostudies-literature
UnknownAssociation of Variant rs4790904 in Protein Kinase C Alpha with Posttraumatic Stress Disorder in a U.S. Caucasian and African-American Veteran Sample.
Not available
S-EPMC4021713 | biostudies-literature
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
UnknownFTO is necessary for the induction of leptin resistance by high-fat feeding.
Not available
S-EPMC4354923 | biostudies-literature
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