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UnknownIdentification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region.
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S-EPMC9697031 | biostudies-literature
ProteomicsProteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients
In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.
ORGANISM(S): Homo Sapiens 
2021-12-29 | PXD030660 |
ProteomicsSS18/BAFs regulate chromatin accessibility dynamics during pluripotent-somatic transition
The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of mammalian development, and is also a representative cell-fate transition model, but remains largely unresolved. Recently, we reported construction of robust JUN-induced PST completed in one cell cycle and whose ...
ORGANISM(S): Mus Musculus 
PXD029277 |
ProteomicsJuvenile hormone membrane signaling phosphorylates USP to potentiate 20-hydroxyecdysone action and Yorkie activity in Drosophila
Juvenile hormone (JH) antagonizes 20-hydroxyecdysone (20E) signaling mainly through the intracellular receptors Met and Gce in Drosophila. To investigate JH membrane signaling pathway without the interference from JH intracellular signaling, we characterized phosphoproteome profiles of the Met gce d...
ORGANISM(S): Drosophila Melanogaster 
PXD021644 |
ProteomicsERK binding protein identification
Identification of the ERK binding protein in regenerated leg
ORGANISM(S): Periplaneta Americana 
2024-03-07 | PXD050429 |
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
2021-05-23 | PXD026208 |
ProteomicsSpatial distribution of the proteome in human body and cancers
The ddaPASEF and diaPASEF data were acquired from over 60 types of human specimens. Based on these, the consensus spectral libraries were generated and used in subsequent DIA analysis to demonstrate a quantitative human proteome map and discover potential cancer biomarkers.
ORGANISM(S): Homo Sapiens 
PXD077178 |
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