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MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
ProteomicsDifferential proteomics of HeLa cells treated with PDS for 24 hours and untreated HeLa cells
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, combining mass spectrometry based proteomics strategy with bioinformatics analysis, we revealed that PDS significantly downregulated 22 proteins, of which the genes contai...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029521 | Pride
Hela Lc-ms/ms 
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
ProteomicsIdentification of the Voltage Dependent Anion Channel (VDAC1) protein implicated in the pathology of Hepatocellular carcinoma (HCC) by quantitative proteomics and integrating genetic analysis
Hepatocellular carcinoma (HCC) is a heterogeneous tumor associated with multiple signaling pathway alterations, among which mitochondrial dysfunction has been found to play an important role.
ORGANISM(S): Homo Sapiens 
2020-01-12 | PXD017072 |
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