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ProteomicsStabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis
DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organizatio...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD013856 | Pride
Dgcr8 Heterochromatin Aging 
TranscriptomicsGene expression analysis of H9 hESC derived cardiomyocytes (CM) and neuron stem cells (NSC)
In this study, we generated wildtype H9 hESC derived cardiomyocytes (CM) and neural stem cells (NSC) by in vitro differentiation. Global gene expression profiles were compared among undifferentiated H9 hESC and the derived CM and NSC. Comparison of global gene expression profiles of undifferentiated...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-48257 | biostudies-arrayexpress
ProteomicsLC-MS/MS identification of MAVS-interacting proteins
The nanoLC-MS/MS experiments were performed on a Q Exactive mass spectrometer (Thermo Scientific) in data-dependent mode, which allowed MS data acquisition at a high resolution of 70,000 (m/z 200) across an m/z range of 300–1600. The raw data from Q Exactive analysis were analyzed with Proteome Disc...
ORGANISM(S): Homo Sapiens 
PXD041140 |
TranscriptomicsRecapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-24487 | biostudies-arrayexpress
ProteomicsLC-MS/MS identification of XPO7-interacting proteins
Identification XPO7-interating proteins by ectopically expressed FLAG-tagged XPO7 proteins in HEK293T cells and performed coimmunoprecipitation (co-IP) with FLAG antibody followed by mass spectrometry analysis.
ORGANISM(S): Homo Sapiens 
2022-11-03 | PXD037890 |
ProteomicsThe proteomes of tea cultivars Zijuan and Yunkang10
The shoot of tea cultivars Zijuhttps://www.iprox.cn/page/PCV010.html?projectId=IPX0005046000an and Yunkang10 are purple and green, respectively, and there are differences in flavonoid content. By comparing the proteomes of them, the molecular mechanism of the difference in flavonoids is explored.
ORGANISM(S): Camellia Sinensis Var. Assamica 
2022-09-14 | PXD036754 |
ProteomicsProteomics dataset of COVID-19 and control patients
Proteomics dataset of COVID-19 and control patients
ORGANISM(S): Homo Sapiens 
PXD029023 |
ProteomicsThe proteomic navigator of human aging
Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of mult...
ORGANISM(S): Homo Sapiens 
2024-12-06 | PXD058638 |
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