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UnknownOptimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Not available
S-EPMC9245059 | biostudies-literature
ProteomicsCCPRD: A novel analytical framework for comprehensive proteomic reference database construction of non-model organisms
Protein reference databases are a critical part of producing efficient proteomic analyses. However, the method for constructing clean, efficient, and comprehensive protein reference databases is lacking. Existing methods either do not have contamination control procedures, or these methods rely on a...
ORGANISM(S): Myxobolus wulii Myxobolus honghuensis Thelohanellus kitauei 
2020-07-09 | PXD018851 | Pride
Proteomics Reference database Nematocysts Ccprd Myxozoans Protein identification 
ProteomicsN-myristoylation by NMT1 is POTEE-dependent to stimulate liver tumorigenesis via differentially regulating ubiquitination of targets
We immuno-precipitated NDP including LXN, RPL29 and FAU, respectively, and NUP including AHSG, ALB and TF, respectively, before setting the immuno-precipitates to the Mass spectrometry (MS).
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD011906 | Pride
Post-translational modifications (ptms)  n-myristoyltransferase (nmt)  ubiquitin e3 ligase histih4h  proteomics  liver cancer 
ProteomicsiTRAQ experiment to identify proteins that changed before and after NMT1 was knocked down in both Bel-7402 and Bel-7404 cells
We performed proteomics isobaric tags for relative and absolute quantification (iTraq) to identify proteins that changed before and after NMT1 was knocked down in both Bel-7402 and Bel-7404 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD011812 | Pride
Itraq，liver cancer，nmt1 knockdown 
GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
ProteomicsQ-TOF/MS detected results of the Lysostaphin and recombinant Lysostaphin-ELP(V)90
This study engineered a recombinant lysostaphin (Lst) variant, Lst-ELP(V)₉₀, as a therapeutic candidate for prosthetic explant biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Compared with the wild-type (WT) lysostaphin, the recombinant construct exhibited markedly i...
ORGANISM(S): Escherichia coli 
2026-08-13 | PXD080789 | Pride
Lysostaphin Elp Mrsa Q/tof/ms Biofilm 
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
TranscriptomicsTranscriptome analysis of Liangshan pig muscle development at the growth curve inflection point and asymptotic stages using digital gene expression profiling
Animal growth curves can provide essential information for animal breeders to optimize feeding and management strategies. However, the genetic mechanism underlying the phenotypic differentiation between the inflection point and asymptotic stages of the growth curve is not well characterized. Here, w...
ORGANISM(S): Sus scrofa 
2015-05-25 | E-GEOD-69113 | biostudies-arrayexpress
ProteomicsThe global succinylation of SARS-CoV-2-infect host cells reveals potential drug targets
Here we show a quantitative mass spectrometry-based succinylproteomics analysis of SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape of succinylation on host and viral proteins.
ORGANISM(S): Homo Sapiens 
2021-12-06 | PXD030197 |
ProteomicsProteomics dataset of COVID-19 and control patients
Proteomics dataset of COVID-19 and control patients
ORGANISM(S): Homo Sapiens 
2021-10-14 | PXD029023 |
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