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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
UnknownThree dimensional collagen scaffolds promote iPSC induction with higher pluripotency.
Not available
S-EPMC5084158 | biostudies-literature
UnknownEvery road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes.
Not available
S-EPMC9006546 | biostudies-literature
ProteomicsA Chemical Proteomics Approach for Global Mapping of Functional Lysines on Cell Surface of Living Cell
Cell surface proteins are responsible for many crucial physiological roles, and they are also the major category of drug targets as the majority of therapeutics target membrane proteins on the surface of cells to alter cellular signaling. How-ever, despite its great significance, ligand discovery ag...
ORGANISM(S): Homo Sapiens 
2024-03-01 | PXD042888 |
UnknownThe effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies.
Not available
S-EPMC6538583 | biostudies-literature
ProteomicsNascent glycoproteome reveal the suppressed expression of glycosylated LAMP2 in response to N-linked glycosylation inhibition
(1) Analysis of newly synthesized proteins under glycosylation inhibition (2) Analysis of newly synthesized glycoproteins during NGI-1 treatment
ORGANISM(S): Homo Sapiens 
2021-09-04 | PXD028212 |
ProteomicsHigh-Throughput Intact Glycopeptide Quantification Strategy with Targeted-MS (HTiGQs-Target) Reveals Site-Specific IgG N-Glycopeptides as Biomarkers for Hepatic Disorder Diagnosis and Staging
We developed a high-throughput targeted quantification strategy for intact glycopeptides (HTiGQs-Target) to diagnose and differentiate the malignancy of liver diseases. The method involves two-step labeling. This step derivatization makes the same parent ions in different samples produce sufficient ...
ORGANISM(S): Homo Sapiens 
2023-05-30 | PXD042528 |
ProteomicsAnalysis of intact S-acylated peptides by ssMLCC
Enrichment of metabolically labelled intact S-acylated peptides and subsequent analysis by LC-MS/MS
ORGANISM(S): Homo Sapiens 
2023-12-10 | PXD047685 |
ProteomicsNascent proteome and glycoproteome reveal the inhibition role of ALG1 in hepatocellular carcinoma cell migration
(1) ALG1-related changes of the nascent proteome in Huh7 cell line (2) Knockdown of ALG1 inhibited the expression of glycosylated N-cadherin
ORGANISM(S): Homo Sapiens 
2021-10-11 | PXD029045 |
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