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MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
TranscriptomicsMeDIP-chip of zdp mutant
Using meDIP-chip to provide methylation profile in zdp mutant and identify hypermethylated regions comparing to wild type Arabidopsis plants. Examination of zdp mutant's methylome. 4 samples(1 mutant, 1 WT, each has two biological replicates)
ORGANISM(S): Arabidopsis thaliana 
2012-03-20 | E-GEOD-33719 | biostudies-arrayexpress
GenomicsWhole genome bisulfite sequencing of idm1, rdd, ros1 mutants and Col-0 WT
Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in ros1, idm1, and rdd mutants and identify hypermethylated regions comparing to wild type Arabidopsis plants. Examination of 3 different mutants' methylome. 8 samples (3 mutants, 1 WT, each has two b...
ORGANISM(S): Arabidopsis thaliana 
2012-06-17 | E-GEOD-33071 | biostudies-arrayexpress
GenomicsDTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo DNA methylation in plants can be achieved by the RNA-directed DNA methylation (RdDM) pathway, where the plant-specific DNA-dependent RNA polymerase Pol IV transcribes target sequences to initiate 24-nt siRNA produ...
ORGANISM(S): Arabidopsis thaliana 
2013-06-03 | E-GEOD-44209 | biostudies-arrayexpress
TranscriptomicsArabidopsis EDM2 Promotes IBM1 Distal Polyadenylation and Regulates Genome DNA Methylation Patterns [RNA-Seq]
A forward genetics screen led to the identification of the putative chromatin regulator EDM2 as a cellular anti-silencing factor and regulator of genome DNA methylation patterns. EDM2 contains a composite PHD finger domain that recognizes both active H3K4 and repressive H3K9 methylation marks at the...
ORGANISM(S): Arabidopsis thaliana 
2013-10-29 | E-GEOD-51763 | biostudies-arrayexpress
TranscriptomicsHigh-throughput RNA sequencing analysis of WT, rdm16-2 and sta1 mutants
Using Illumina paired-end RNA-seq technology to examine the genome-wide gene expression and intron-retention events in WT, rdm16-2 and sta1 RNA-seq analysis of 4-week-old leaves of WT, rdm16-2 and sta1 mutants
ORGANISM(S): Arabidopsis thaliana 
2013-02-26 | E-GEOD-44635 | biostudies-arrayexpress
GenomicsWhole genome bisulfite sequencing of rdm16ros1, ros1, nrpd1ros1 mutants and C24 wild-type
Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in rdm16ros1, ros1, nrpd1ros1 mutants and examine the effect of RDM16 on DNA methylation 4 samples examined: C24 wild type with RD29A-LUC transgene, rdm16ros1 double mutant, ros1 mutant, nrpd1ros1 mut...
ORGANISM(S): Arabidopsis thaliana 
2013-09-27 | E-GEOD-44417 | biostudies-arrayexpress
ProteomicsReciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response
We found that TOR kinase regulates the plant environmental stress responses through phosphorylation at a conserved serine residue of Abscisic acid receptor PYR1/PYLs/RCARs. The phosphorylation inhibits the function of PYLs and prevents the binding of PYLs to abscisic acid and its downstream substrat...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-01 | PXD003746 | Pride
Snrk2 Aba receptor Raptor Abscisic acid Target of rapamycin Phosphorylation 
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
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