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TranscriptomicsRaptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions
Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Rap...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51668 | biostudies-arrayexpress
GenomicsCampoletis raptor
Campoletis raptor overview
PRJNA922296 | ENA
TranscriptomicsGene-expression changes resulting from loss of the mTORC1 component Raptor in murine hematopoietic stem and progenitor cell-enriched populations (HSPC)
We investigated the role of mTORC1 in murine hematopoiesis by conditionally deleting the Raptor gene in murine hematopoietic stem cells. We observed mutliple alterations evoked by Raptor loss in hematopoiesis and profiled gene-expression alterations induced by raptor loss in Flt3-Lin-Sca1+cKit+ hema...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-32265 | biostudies-arrayexpress
ProteomicsRaptor and rapamycin dependent proteomic changes in Akt overexpressing skeletal muscle
Analysis of proteomic changes upon deletion of Raptor or inhibition by rapamycin in mouse muscles over expressing a constitutively active Akt.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-08 | PXD028796 | Pride
Akt Raptor Skeletal muscle Mtor 
TranscriptomicsResponse to salt stress of Raptor mutants
ra12-03_raptor-nacl - Characterization to raptor mutants (partner of the kinase TOR) and of their answer to the salt stress. - Sowing on metal grids on MS/2 medium with continuous light. Transfer after 12 days of culture for 3h to liquid MS/2 medium containing or not 200 mM NaCl. 7 dye-swap - gene k...
ORGANISM(S): Arabidopsis thaliana 
2013-07-01 | E-GEOD-47391 | biostudies-arrayexpress
GenomicsiyCamRapt
Campoletis raptor
PRJEB56062 | ENA
TranscriptomicsmTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
The mechanistic target of rapamycin mTORC1 is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTOR inhibitors, the role of mTORC1 in renal tubular function and kidney homeostasis remains elusive. By utilizing constitutive and inducible deletion of conditional Rap...
ORGANISM(S): Mus musculus 
2014-06-09 | E-GEOD-54417 | biostudies-arrayexpress
UnknownThe population density of an urban raptor is inextricably tied to human cultural practices.
Not available
S-EPMC6501671 | biostudies-literature
GenomicsiyCamRapt1
Campoletis raptor genome assembly, iyCamRapt1
PRJEB58800 | ENA
ProteomicsO-GlcNAcylation of Raptor transduces glucose signals to mTORC1
Complex molecular mechanisms ensure cellular homeostasis between nutrient sensing and energy metabolism. Strong evidence from many laboratories supports a role for the hexosamine biosynthetic pathway (HBP) and its end product, UDP-GlcNAc, as important nutrient sensors. Isotopic photocleavable taggin...
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD039536 | Pride
Mtorc1 Raptor Isoptop Glucose O-glcnac 
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