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ProteomicsKAT8-mediated PCBP1 acetylation drives neutrophil recruitment in papain-induced airway inflammation
Emerging evidence implicates KAT8 as a critical modulator of inflammatory responses in lung diseases. Bosch et al. reported that MG149, a KAT8 inhibitor, reduces pro-inflammatory gene expression in lipopolysaccharide (LPS)-stimulated murine lung slices. Additionally, Liu et al. demonstrated that KAT...
ORGANISM(S): Homo Sapiens 
2026-05-18 | PXD078474 |
ProteomicsMS analysis of endogenously precipitated DDX20 protein complexes (immunoprecipitation (IP)–MS)
Protein lysates were derived from HEK293T cells and spermatogonial stem cells，and interacting proteins were “pulled-down” for analysis by gel electrophoresis and identification by mass spectrometry. An equal amount of non-specific IgG from rabbit serum (Thermos Fisher Scientific) was used as a negat...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-04-24 | PXD038171 |
ProteomicsProteomic analysis of the effects of DDX20 deletion in spermatogonia
To investigate the role of DDX20 in spermatogenesis, we generated Ddx20 flox/flox Ddx4-Cre mice to make a germ cell-specific Ddx20 knockout, and isolated spermatogonia from four-day-old mouse testes by THY1 magnetic beads. We then performed proteomic analysis using protein lysates obtained from THY1...
ORGANISM(S): Mus Musculus 
2024-04-24 | PXD038170 |
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