Liu Jinshi J - OmicsDI

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2022 (2)
2025 (1)

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Characterization and functional validation of β-carotene hydroxylase AcBCH genes in Actinidia chinensis.

Carotenoids are the pigment substances of yellow-fleshed kiwifruit, and among them β-cryptoxanthin has only been detected in the brighter yellow-fleshed variety 'Jinshi 1'. β-Carotene hydroxylase (BCH) catalyzes the formation of β-cryptoxanthin and zeaxanthin, but its molecular characteristics and f...

S-EPMC9123235 | biostudies-literature

G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex.

Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, applying MS proteomics strategy, we revealed PDS significantly downregulated 22 proteins but upregulated 16 proteins in HeLa cancer cells, of which the genes both contain ...

S-EPMC8989551 | biostudies-literature

The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts.

Background

Osteoporosis (OP) is a disease in which weak bones increase the risk of fracture. It has been reported that the occurrence of ferroptosis accelerated the progression of OP. However, the underlying mechanism of ferroptosis in OP remains unclear.