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TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
TranscriptomicsCritical Requirement of the DNA Methyltransferase, Dnmt1, for the Development and Function of Foxp3+ Regulatory T Cells
We investigated the role of DNMT1 in immune homeostasis by generating mice lacking DNMT1 in Foxp3+ T-regulatory (Treg) cells. These mice showed decreased peripheral Foxp3+ Tregs, complete loss of Foxp3+ Treg suppressive functions in vitro and in vivo, and died from autoimmunity by 3-4 weeks unless t...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-27434 | biostudies-arrayexpress
UnknownIsorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway.
Not available
S-EPMC11011973 | biostudies-literature
TranscriptomicsSindbis virus induces the production of a novel class of endogenous siRNAs in Aedes aegypti mosquitoes
We examined the biogenesis of mRNA-derived endogenous short-interfering RNAs (endo-siRNAs) in the disease vector mosquito, Aedes aegypti. Under standard conditions, mRNA-derived endo-siRNAs were produced from the bidirectional transcription of tail-tail overlapping gene pairs. Upon infection with th...
ORGANISM(S): Aedes aegypti 
2012-04-01 | E-GEOD-35161 | biostudies-arrayexpress
TranscriptomicsTwo Lysines in the Forkhead Domain of Foxp3 are Key to T Regulatory Cell Function
The forkhead transcription factor, Foxp3, is pivotal to the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. Previous data indicated that many of the functions of Foxp3 are controlled by the acetylation of several lysines within...
ORGANISM(S): Mus musculus 
2011-02-05 | E-GEOD-27082 | biostudies-arrayexpress
UnknownFlat-band quantum materials empowering self-adapted ultrabroadband detectors.
Not available
S-EPMC12504747 | biostudies-literature
TranscriptomicsMbd2 promotes Foxp3 demethylation and T-regulatory cell function
The proposed use of Foxp3+ T-regulatory (Treg) cells as potential cellular therapy in patients with autoimmune diseases, or post-hemopoietic stem cell or organ transplantation, requires a sound understanding of the transcriptional regulation of Foxp3 expression. Conserved CpG dinucleotides in the Tr...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-48653 | biostudies-arrayexpress
UnknownUniversal inter-molecular radical transfer reactions on metal surfaces.
Not available
S-EPMC11001993 | biostudies-literature
TranscriptomicsSirt1 targeting promotes Treg function
Sirtuin-1 (Sirt1), a class III histone/protein deacetylase is central to cellular metabolism, stress responses and aging, but its contributions to various host immune functions have been little investigated. To study the role of Sirt1 in T-cell functions, we undertook targeted deletions by mating mi...
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-26425 | biostudies-arrayexpress
ProteomicsIntegrated Multilayer Omics Reveals the Genomic, Proteomic and Metabolic Influences of the Histidyl Dipeptides on Heart
Histidyl dipeptides, such as carnosine, present in a micro-millimolar ranges in the heart, are synthesized via the enzyme carnosine synthase (Carns). These dipeptides facilitate glycolysis by proton buffering, form conjugates with reactive aldehydes, such as acrolein, and attenuate ischemia and repe...
ORGANISM(S): Mus <genus> 
2021-12-25 | PXD030647 |
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