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ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsQuantitative proteomics reveals the crucial roles of Cathepsin D in bacterial infections
Bacterial resistance has become more and more widespread which seriously threatens human life and health. Therefore, using the natural immune system of host to kill bacteria is particularly fascinating. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of mitochond...
ORGANISM(S): Mus Musculus 
2020-05-13 | PXD016938 |
ProteomicsProteomics reveals the potential mechanism of Mrps35 controlling Listeria intracellular proliferation in macrophages
We performed the comprehensive proteomics to analyze the dynamic expression landscape of wild type and Mrps35 Knockdown Raw264.7 cells by Listeria infection over 6h. Based on the results of mass spectrometry, we presented a wide variety of hypotheses about the mechanism of Mrps35 controlling the Lis...
ORGANISM(S): Mus Musculus 
2020-10-22 | PXD022127 |
ProteomicsTailoring an Intravenously Injectable Oncolytic Virus for Augmenting Radiotherapy
Oncolytic viruses (OVs) combined with radiotherapy (RT) have shown promise in clinical trials but remain limited by unsatisfactory efficacy. Key challenges include poor intravenous delivery, insufficient RT-induced DNA damage, and suboptimal anti-tumor immune responses. Herein, we developed a novel ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-02-02 | PXD060493 |
ProteomicsFunctional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement
We showed that with genetic manipulation as Pten/Socs3 knockout (KO), CNTF overexpression and Lipin1 knockdown (PSCL), RGCs could regenerate and reinnervate into OPN nuclei after pre-OPN optic tract injury. We then performed single-cell RNA sequencing on OPN-projecting retinal ganglion cells and pro...
ORGANISM(S): Mus Musculus 
PXD052573 |
ProteomicsThe proteomics of Candida albicans
The proteomics of different isolates of Candida albicans
ORGANISM(S): Candida Albicans 
2022-03-07 | PXD032114 |
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