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TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-9809 | biostudies-arrayexpress
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
TranscriptomicsEstrogen-mediated Epigenetic Repression of Large Chromosomal Regions through DNA Looping
The current concept of epigenetic repression is based on one repressor unit corresponding to one silent gene. This notion, however, cannot adequately explain concurrent silencing of multiple loci observed in large chromosome regions. The long-range epigenetic silencing (LRES) can be a frequent occur...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21068 | biostudies-arrayexpress
TranscriptomicsExpression profile of MEFs, iPS, and ES in different culture condition
MEFs can be reprograming to ES by defined reprogramming factors, the derived ES-like cells were termed iPSc. Completely reprogrammed iPSc have identifed gene expression profle with ES. Culture condition may influent the pluripotency of iPSCs.iPS/ES cultured in differient ES medium may have differen...
ORGANISM(S): Mus musculus 
2010-10-27 | E-GEOD-24861 | biostudies-arrayexpress
TranscriptomicsA systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells [HG-U133_Plus_2]
In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the aggressiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression profiling, bioinformatics prediction, and functional assays. Analysis of the miRNA expression...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-40057 | biostudies-arrayexpress
TranscriptomicsA systematic evaluation of miRNA: mRNA interactions involved in the migration and invasion of breast cancer cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-40059 | biostudies-arrayexpress
TranscriptomicsA systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells [HuGene-1_0-st]
In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the aggressiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression profiling, bioinformatics prediction, and functional assays. Analysis of the miRNA expression...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-40058 | biostudies-arrayexpress
TranscriptomicsA systematic evaluation of miRNA: mRNA interactions involved in the migration and invasion of breast cancer cells [miRNA Array]
In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the aggressiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression profiling, bioinformatics prediction, and functional assays. Analysis of the miRNA expression...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-40056 | biostudies-arrayexpress
TranscriptomicsPhenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis
Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory r...
ORGANISM(S): Yersinia pestis 
2011-10-23 | E-GEOD-26601 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cell lines stably expressing shRNA targeting ctrl or UHRF1
We used microarrays to explore the expression profile from cells expressing wild type and UHRF1 S674A mutant. HeLa cells expressing UHRF1 WT and S674A mutant showed similar gene expression pattern without significant affecting the transcription of DNA repari genes. UHRF1 was depleted in HeLa cells...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-73751 | biostudies-arrayexpress
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