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TranscriptomicsMicroRNAs differentially expressed in liposarcoma
We performed expression profiling of microRNAs comparing liposarcomas (n=17) with normal fat pad (n=8). We found 35 miRNAs differentially expression (P<0.0001, fold>1.5), including mir-155. We performed expression profiling of microRNAs comparing liposarcomas with normal fat pad.
ORGANISM(S): Homo sapiens 
2012-03-22 | E-GEOD-31045 | biostudies-arrayexpress
GenomicsGenome-wide anaylsis of histone acetylation during mouse ESC differentiation [ChIP-seq]
Using acetylated histone H3 ChIP-seq, we reveal that the histone H3 acetylation level is gradually increased on the neural gene loci while decreased on the neural-inhibitory gene loci during mouse ESC neural differentiation. By overlapping with the targets of HDAC1 ChIP-seq, we identify Nodal as a t...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-66025 | biostudies-arrayexpress
ProteomicsUsing the HA tagged PAICS immunoprecipitation combined with LC-MS for identification of the acetylation sites of PAICS protein in senescent human IMR90 cells at day 10 post oncogene RAS activation
Senescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. We used proximity labeling by turboID combined with LC-MS and iden...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD048965 | Pride
Human Imr90 Lc-ms 
ProteomicsUsing proximity labeling by turboID (biotin ligase) fused with ACSS2 combined with LC-MS for identification of the proteins associated with ACSS2 in oncogene RAS activation induced senescent human IMR90 cell
Senescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. The metabolic enzyme ACSS2 produces acetyl-coA from acetate and ep...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD048937 | Pride
Human Imr90 Lc-ms 
TranscriptomicsGene expression analysis in differentiated day 3 cells from mouse ESC under the treatment of DMSO and histone deacetylase inhibitors (TSA) [expression array]
Based on the cDNA microarrays performed with the RNAs prepared from the differentiated cells at day 3 with or without 24 hrs TSA treatment initiated at day 2, we reveal that the upregulated gene sets were highly enriched for biological functions related to mesoderm development, mesoderm morphogenesi...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-66026 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of EZH2 activation
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47476 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of EZH2 knockdown
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-46904 | biostudies-arrayexpress
ProteomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer
Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. Here...
ORGANISM(S): Homo Sapiens 
PXD069373 |
ProteomicsSLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth
Taurine plays a crucial role in mitochondrial tRNA modification essential for mitochondrial translation. Mammalian cells obtain taurine through plasma membrane transporter SLC6A6-mediated uptake exogenously or cytosolic biosynthesis. However, it remains unclear how taurine enters mitochondria and im...
ORGANISM(S): Homo Sapiens 
2025-11-29 | PXD071408 |
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