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ProteomicsTMT-Based Quantitative Proteomic Profiling of DNASE1L3-Deficient and Wild-Type Mouse Livers
This study investigates the impact of DNASE1L3 deficiency on hepatic immune–metabolic homeostasis using TMT-based quantitative proteomics. Liver tissues from 8-week-old wild-type (WT) and DNASE1L3 knockout (KO) mice were analyzed by LC-MS/MS. Differential protein expression and pathway enrichment an...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD068786 | Pride
Proteomics Tmt Ferroptosis Liver Kupffer cells Dnase1l3 Lc-ms/ms Nafld 
MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
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