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ProteomicsMultiomics analysis of a DNAH5-mutated PCD organoid model revealed the key role of the TGF-β/BMP and Notch pathways in epithelial differentiation and the immune response in DNAH5-mutated patients
Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed the genetic characteristics and pathogenetic mechanisms of PCD caused by DNAH5 mutation. Here, we established a child P...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038024 | Pride
Primary ciliary dyskinesia Immune response Airway organoid Dnah5 Multiomics analysis 
ProteomicsStructural Alternation in Heat Shock Proteins of Activated Macrophages
The inflammatory response of macrophages is an orderly and complex process under strict reg-ulation accompanied by drastic changes in morphology and functions. It is predicted that pro-teins will undergo structural changes during these finely regulated processes. However, changes in structural prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029672 | Pride
Structural proteomics  raw264.7  lps  lip-ms  hsp60 
ProteomicsPsAF5 functions as an essential adapter for PsPHB2-mediated mitophagy under ROS stress in Phytophthora sojae
Host-derived reactive oxygen species (ROS) is an important defense means to protect against pathogens. Although mitochondria are the main intracellular targets of ROS, how pathogens regulate mitochondrial physiology in response to oxidative stress remains elusive. Prohibitin 2 (PHB2) is an inner mit...
ORGANISM(S): Phytophthora sojae 
2024-05-21 | PXD044242 | Pride
Lc-msms Oomycete Mitochondria Phytophthora sojae 
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
ProteomicsProtein from ovarian tissue of Qira black sheep
Proteins were extracted from fresh and intact ovarian tissues, followed by sequencing analysis
ORGANISM(S): Ovis Aries 
2026-03-28 | PXD076327 |
TranscriptomicsRNA-seq of human breast cancer cell line MCF7, T47D and CAMA-1 treated that are naïve and resistant to capivasertib and have been treated with acute capivasertib, continuous capivasertib and DMSO
MCF7, T47D and CAMA-1 cell lines were treated with long-term (continuous) capivasertib to induce resistant cell-lines (T47D P1, MCF7 P1 and CAMA-1 P1). The naïve (or parental) cell lines had RNAseq sequencing at treatment with DMSO and treatment with capivasertib. Resistant cell lines had RNAseq seq...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16414 | biostudies-arrayexpress
ProteomicsCHTOP interaction proteins in injured mouse brain by MS
The project investigated the role of CHTOP in the regulation of neuronal cell death after brain injury. To investigate the mechanism of CHTOP in the regulation of neuronal death, we performed immunoprecipitation to pulldown CHTOP interacting proteins in both neurons and other brain resident cells. T...
ORGANISM(S): Mus Musculus 
2023-02-23 | PXD040340 |
ProteomicsTranscription Factor Response Elements on Tip: A Sensitive Approach for Large-Scale Endogenous Transcription Factor Quantitative Identification
The ability to map endogenous transcription factors (TFs) DNA binding activity at the proteome scale will greatly enhance our understanding of various biological processes. Here we report a highly sensitive, rapid, and high-throughput approach, transcription factor response elements on tip-mass spec...
ORGANISM(S): Homo Sapiens 
2021-08-25 | PXD028104 |
ProteomicsLarge-scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis
Neurosyphilis (NS) is a central nervous system infection caused by Treponema pallidum. NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as “the great imitator”, NS can be easily overlooked or misdiagnosed due to the absence of standard d...
ORGANISM(S): Homo Sapiens 
2024-02-16 | PXD033034 |
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