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ProteomicsProfiling the molecular states in the mouse ischemia and reperfusion cortex reveals a core regulation module of metabolic reprogramming
Molecular changes caused by metabolic reprogramming in ischemia and reperfusion cortex remain an unaddressed issue. Applying the quantitative proteomic and lactylproteomic analysis, we found that the molecular changes of ischemic brain tissues are quite different between ischemia and reperfusion sta...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD019323 | Pride
Aldolase c Ischemia Metabolic reprogramming Lactylation Reperfusion 
UnknownAge-standardized mortality, disability-adjusted life-years and healthy life expectancy in different cultural regions of Guangdong, China: a population-based study of 2005-2015.

Background

Guangdong province is dominated by three cultural regions: Canton, Hakka and Hoklo. However, little is known about the disease burden within these regions, particularly because different population,environmental and socioeconomic risk factors might cause different patterns of mort...
S-EPMC7275520 | biostudies-literature
UnknownChemical Distance Measurement and System Pharmacology Approach Uncover the Novel Protective Effects of Biotransformed Ginsenoside C-Mc against UVB-Irradiated Photoaging.
Long-term exposure to ultraviolet light induces photoaging and may eventually increase the risk of skin carcinogenesis. Rare minor ginsenosides isolating from traditional medicine Panax (ginseng) have shown biomedical efficacy as antioxidation and antiphotodamage agents. However, due to the difficul...
S-EPMC8850047 | biostudies-literature
UnknownRegulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.
Yin Yang 1 (YY1) is a multifunctional transcription factor shown to be critical in a variety of biological processes. Although it is regulated by multiple types of post-translational modifications (PTMs), whether YY1 is methylated, which enzyme methylates YY1, and hence the functional significance o...
S-EPMC4763200 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
TranscriptomicsReprogramming fibroblasts into bi-potential hepatic stem cells by defined factors
Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem/progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gat...
ORGANISM(S): Mus musculus 
2013-07-19 | E-GEOD-48486 | biostudies-arrayexpress
ProteomicsElectroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
Electroacupuncture Activated Local Sympathetic Noradrenergic Signaling to relieve synovitis and referred pain behaviors in KOA Rats
ORGANISM(S): Rattus Norvegicus 
2022-11-29 | PXD038461 |
ProteomicsGlobal profiling of protein lactylation in Human hippocampi
Lysine lactylation (Kla) is a novel posttranslational modification, playing important roles in numerous biological processes, including transcription, metabolism, tumorigenesis and nervous system diseases. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified l...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050470 |
Proteomicsthe MS data involved in the article "Nuclear ACAT1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer"
In this study we aim to explore the metabolic enzyme that affects NK cell function in colorectal cancer, and mainly focus on the mechanism how nuclear ACAT1（Mitochondrial acetyl-CoA acetyltransferase）promotes NK cell infiltration and activation
ORGANISM(S): Homo Sapiens 
2025-03-18 | PXD061959 |
ProteomicsThe pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Proteome analysis of Biotin- PLANE pull-down assays
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022747 |
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