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ProteomicsHuman fetal left and right frontal lobes LC-MSMS
Inherent hemispheric asymmetry is significant for cognition, language and other functions. An understanding of normal brain and asymmetry development in the early period will further the knowledge of how different hemispheres prioritize specific functions, which is still unknown. We analysed the dev...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD034192 | Pride
Fetal frontal lobe 
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
ProteomicsQuantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting PDGFRβ/PI3K/AKT pathway
Yinchenzhufu decoction (YCZFD) is a traditional Chinese medicine formula with hepatoprotective effects. In this study, the protective effects of YCZFD against cholestatic liver fibrosis and its mechanisms of action were evaluated in a mouse model of 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC)-i...
ORGANISM(S): Mus Musculus 
2023-10-13 | PXD046101 |
ProteomicsA Time-resolved Multi-omic Atlas of the Developing Mouse Liver
Liver organogenesis and development is composed of a series of complex, well-orchestrated events. Identification of key factors and pathways governing liver development will help understand this process and may also provide insights for other physiological and pathological processes including cancer...
ORGANISM(S): Mus Musculus 
2019-06-06 | PXD014144 |
ProteomicsA Time-resolved Multi-omic Atlas of the Developing Mouse Stomach
We collected 3 replicates of whole stomach organs at 15 time points that covered embryonic days (E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5), postnatal days (D1, D3, D5), and postnatal weeks (W1, W2, W3, W6, W8). The sampling time window covered from the earliest day that stomach sampling is an...
ORGANISM(S): Mus Musculus 
2018-08-06 | PXD010702 |
ProteomicsA region-resolved mucosa proteome of the human stomach
The human gastric mucosa is the most active and functional layer that carries out food digestion and metabolic processes in physiological conditions and also the main origin of carcinogenesis in gastric cancer. Anatomically, the human stomach is divided into 7 regions with physiological functions, b...
ORGANISM(S): Homo Sapiens 
2018-11-26 | PXD011821 |
ProteomicsSERBP1–PCIF1 complex–controlled m6Am modification in S1HLGlu neurons is required for neuropathic pain in mice
Nerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional layer of gene regulation. However, the role of ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-06-30 | PXD065634 |
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