Sort   by:  
 Page size 
ProteomicsBeclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057003 | Pride
Beclin 1 Mouse Fetal liver 
ProteomicsDevelopment of a high-throughput (10 minute microflow gradient) platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrom...
ORGANISM(S): Homo Sapiens 
2025-10-31 | PXD056434 | panorama
ProteomicsDeacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that different proteins and their acetylation modification r...
ORGANISM(S): Homo Sapiens 
2023-02-20 | PXD040298 |
ProteomicsWDR76_SPIN1_Halo-AP_Enriched_Histones_AscendDIA
Histone PTM bottom-up profiling of Halo-WDR76 or Halo-SPIN1 Enriched or total histones (w Propionylation; no spike-in peptide) Supplementry data for WDR76-SPIN1 SCAP Analysis
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-15 | MSV000094548 | MassIVE
ProteomicsWDR76-SPIN1_inWDR76KO_SCAP-MS_MudPIT
Serial Capture Affinity Purification (SCAP) samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits are SNAP-SPIN1 and Halo-WDR76. SNAP purification was performed first, then Halo purification was performed. SCAP was performed using whole cel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-03 | MSV000086802 | MassIVE
ProteomicsHalo-WDR76_Purification_WDR76KObackground_MudPIT_wPTMs
Halo purification samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits Halo-WDR76. Purification was performed using whole cell extract from a stable cell line of 293FRT cells in WDR76 KO background. Control purification was performed on bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086849 | MassIVE
ProteomicsHalo-Control/WDR76/SPIN1/CBX5_purification_MudPIT_wPTMs
Halo purification samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits are Halo-WDR76, Halo-SPIN1, Halo-CBX5. The bait for Control Purification is Halo tag only. Purification for each bait was performed using whole cell extract from a stab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086846 | MassIVE
ProteomicsHalo-WDR76_Purification_inWDR76KO_DSSO-XL-MS
Halo purified WDR76 from a stable cell line of 293FRT in WDR76 KO background. DSSO crosslinking performed in eluted samples. Data collected using ms1/ms2/ms3 method. Data searched using Proteomics Discoverer 2.4 with XlinkX.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-09 | MSV000086828 | MassIVE
ProteomicsWDR76-SPIN1_SCAP-E2-XL_mzTab and mgf
SCAP-XL of Halo-WDR76 and SNAP-SPIN1 from stable cell line in WDR76 KO background. Serial Capture Affinity Purification (SCAP) was performed on whole cell extract of a stable cell line of 293FRT cells in WDR76 KO background. DSSO crosslinked in E2 sample. Data was acquired using a ms1/ms2/ms3 method...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-22 | MSV000086749 | MassIVE
ProteomicsDevelopment of a high-throughput (10 minute microflow gradient) platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-06 | MSV000094695 | MassIVE
Sort   by:  
 Page size