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GenomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RRBS]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61330 | biostudies-arrayexpress
MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
GenomicsRole of Tet1 in genomic imprinting erasure [RRBS-sperm]
Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishm...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-49763 | biostudies-arrayexpress
TranscriptomicsTet proteins in DNA demethylation and cell fate restriction
DNA methylation at 5-position of cytosine (5mC) is one of the best studied epigenetic modifications that plays important roles in diverse biological processes. Iterative oxidation of 5mC by the Ten-eleven translocation (Tet) family of proteins generates 5-hydroxymethylcytosine (5hmC), 5-formylcytosi...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-56986 | biostudies-arrayexpress
TranscriptomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RNA-seq]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61329 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by Agilent mouse miRNA microarray
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
2010-11-30 | E-GEOD-19427 | biostudies-arrayexpress
ProteomicsProtein profiling reveals the characteristic changes of complement cascade pathway in the tissues of gastric signet ring cell carcinoma
Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared to adenocarcinomas (ACs). Lacking of systematically molecular overview to this disease made a slow progress in its clinical practice. In the present proteomics study, gas...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD022952 | Pride
Signet ring cell Mass spectrometry Stomach neoplasms Proteomics Complement system proteins 
ProteomicsProtein profiling reveals the characteristic changes of complement cascade pathway in the tissues of gastric signet ring cell carcinoma
Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared to adenocarcinomas (ACs). Lacking of systematically molecular overview to this disease made a slow progress in its clinical practice. In the present proteomics study, gas...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD022627 | Pride
Signet ring cell Mass spectrometry Stomach neoplasms Proteomics Complement system proteins 
ProteomicsProtein profiling reveals the characteristic changes of complement cascade pathway in the tissues of gastric signet ring cell carcinoma
Signet ring cell carcinoma (SRCC) is a histological subtype of gastric cancer with distinct features in multiple aspects compared to adenocarcinomas (ACs). Lacking of systematically molecular overview to this disease made a slow progress in its clinical practice. In the present proteomics study, gas...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD022405 | Pride
Signet ring cell Mass spectrometry Stomach neoplasms Proteomics Complement system proteins 
GenomicsRole of Tet1 in genomic imprinting erasure [RRBS-PGC]
Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishm...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-49762 | biostudies-arrayexpress
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