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ProteomicsRipening stage-resolved proteome and phosphoproteome profiling of tomato fruits reveals the involvement of reduced chloroplast coverage protein REC1a in fruit ripening
Fruit ripening in tomato (Solanum lycopersicum) has been extensively studied at the molecular, biochemical, physiological, and transcriptomic levels, but comprehensive profiling of tomato fruit proteome and phosphoproteome remain limited. Plastid development and differentiation are critical for toma...
ORGANISM(S): Solanum Lycopersicum 
2024-04-19 | PXD051570 |
ProteomicsAcute proteome responses to de novo sphingolipid synthesis inhibition suggest cancer combination therapies
Sphingolipids are essential structural and signaling lipids that support membrane integrity and govern cell fate decisions. Whereas the consequences of chronic sphingolipid inhibition have been extensively explored, the immediate cellular responses to reduced sphingolipid levels remain poorly define...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD079016 | Pride
Cancer Myriocin Proteome De novo sphingolipid synthesis 
Genomicsena-DATASET-BGI-26-11-2015-07:58:13:440-13 - samples
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAD00001001691 | EGA
GenomicsWhole-genome sequencing in 14 cases and whole-exome sequencing in 90 cases of Chinese ESCC
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAS00001001487 | EGA
ProteomicsZJ5 and 025 interact protein LC-MS
IP and LS-MS to identify the interact protein of ZJ5 and 025 in Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces Cerevisiae 
2024-06-11 | PXD053002 |
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
TranscriptomicsCritical role for the DNA receptor AIM2 in stem-cell proliferation and cancer
Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69436 | biostudies-arrayexpress
ProteomicsProteomics analysis report of esophageal squamous cell carcinoma treated by Dasabuvir
In order to detect the effect of Dasabuvir on the protein expression of esophageal cancer cells, we used control and drug-added KYSE150 cells for proteomic analysis
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031186 |
ProteomicsProteome of TGF-β1-Induced Human Primary Mesothelial Cells treated with and without BCAT1/2 inhibitor
Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, primarily driven by TGF-β1-induced mesothelial-to-mesenchymal transition. BCAT1 and BCAT2 are key enzymes in branched-chain amino acid metabolism, yet their specific roles and mechanisms in peritoneal fibrosis remain unc...
ORGANISM(S): Homo Sapiens 
2025-10-23 | PXD069866 |
TranscriptomicsSystematic evaluation of variability in simulated ChIP-chip experiments
The most widely-used method for detecting and measuring genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Many tiling array platforms, amplification methods, and analysis algorithms exist for ChIP-chip, but a rigorous assessment...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-9842 | biostudies-arrayexpress
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