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ProteomicsEasySCP Unveils Extensive Liver Zonation at Single-cell Proteomics Resolution
The widespread adoption of single-cell proteomics (SCP) in biology has been limited by complex workflows and reliance on specialized instrumentation. Here we present EasySCP, a high-throughput and lossless method that integrates FACS-based single-cell sorting, an all-in-one, single-step digestion pr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-06 | PXD070185 | Pride
Single cell  liver zonation 
ProteomicsLiver zonation patterns and cell size variability in isolated human hepatocytes
Human hepatocytes differ in gene expression and function across the hexagonal lobules of the tissue microarchitecture, a phenomenon referred to as liver zonation. Hepatocytes also display intra-lobular differences in cell size, but to what extent zonal expression and function correlate with cell siz...
ORGANISM(S): Homo sapiens (Human) 
2021-01-26 | PXD013142 | Pride
Human Hepatocytes Cell size variability Liver Zonation 
ModelsKolbe2019 - Spatio-temporal liver zonation
Metabolism of the adult liver in mice and human is spatially zonated with hepatocytes along the axis from each portal vein to the nearest central vein expressing enzymes in a zonated manner. Upstream of that functional zonation, interactions of Wnt and Hh signaling are orchestrating and self-organiz...
2021-09-30 | MODEL2009110001 | BioModels
ProteomicsSingle-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Understanding protein distribution patterns across tissue architecture is crucial for deciphering organ function in health and disease. Here, we applied single-cell Deep Visual Proteomics to perform spatially-resolved proteome analysis of individual cells in native tissue. We built a robust framewor...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD062231 | Pride
Deep visual proteomics Single cell proteomics Spatial protein gradients Fibrosis Human liver zonation 
GenomicsGlucagon contributes to liver zonation in mice [Gcg KO]
Glucagon contributes to liver zonation in mice [Gcg KO]
PRJNA434234 | ENA
GenomicsGlucagon contributes to liver zonation in mice [Gcg infusion]
Glucagon contributes to liver zonation in mice [Gcg infusion]
PRJNA434235 | ENA
GenomicsRNA-Sequence of the liver after administration of adenovirus associated with metabolic liver zonation
RNA-Sequence of the liver after administration of adenovirus associated with metabolic liver zonation
PRJNA1190952 | ENA
GenomicsPerturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
PRJNA1041737 | ENA
GenomicsEnhancer grammar of liver cell types and hepatocyte zonation states
Enhancer grammar of liver cell types and hepatocyte zonation states
PRJEB57734 | ENA
GenomicsEnhancer grammar of liver cell types and hepatocyte zonation states [multiome_validation]
Enhancer grammar of liver cell types and hepatocyte zonation states [multiome_validation]
PRJNA989581 | ENA
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