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ProteomicsProteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting Anti-tubercular drug induced liver injury
In the present study, the proteomics approach identified potential protein signatures with high discriminative ability in TB patients with and without drug-induced liver injury which might play a crucial role in developing Anti-tubercular drug-induced liver injury.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-12 | MSV000088373 | MassIVE
TranscriptomicsGene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling
Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV...
ORGANISM(S): Homo sapiens 
2013-11-14 | E-GEOD-44074 | biostudies-arrayexpress
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
TranscriptomicsTranscription profiling of mouse liver to identify gene expression associated with Strain-Specific Ehrlichia chaffeensisa induced Hepatitis
Infection of humans with Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, can cause hepatitis of varying severity. When the three human isolates of E. chaffeensis, each belongs to different geno-groups, are inoculated into severe combined immunodeficiency mice, the severit...
ORGANISM(S): Mus musculus 
2009-08-22 | E-GEOD-8966 | biostudies-arrayexpress
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsTandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients ...
ORGANISM(S): Homo Sapiens 
2024-01-04 | PXD034882 | panorama
TranscriptomicsTranscription profiling time series of orotic acid induced fatty liver disease in Rattus norvegicus
A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included.
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-665 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
TranscriptomicsMicro RNA expression from human hepatocellular carcinoma (HCC) specimens from patients undergoing liver transplantation.
Current selection criteria for liver transplant in patients with HCC (the Milan criteria) do not incorporate biologic metrics. MiRNA expression profiles correlate with HCC recurrence after transplant and can add significant value to the Milan criteria. MiRNA expression profiles were studied in HCC s...
ORGANISM(S): Homo sapiens 
2011-10-14 | E-GEOD-30297 | biostudies-arrayexpress
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