Sort   by:  
 Page size 
ProteomicsTandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal condition characterized by premature aging with an average age of death of 14.5 years. Patients with HGPS age at a rate 5 to 10 times faster than normal individuals and are thought to undergo an accelerated version of normal aging.To in...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-16 | PXD061485 | Pride
S100a6 Mouse Lmnag609g/g609g mice Hgps 
TranscriptomicsEndothelial YAP/TAZ activation is a key mediator of atherosclerosis in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant protein produced by a de novo point mutation in the LMNA gene. HGPS patients show accelerated aging and die prematurely, mainly from atherosclerosis complications. Understanding...
ORGANISM(S): Mus musculus 
2024-10-17 | E-MTAB-13678 | biostudies-arrayexpress
TranscriptomicsUnderstanding the transcriptional consequences of the Progeria LmnaG609G mutation within the immune compartment of the lung using single cell RNA sequencing.
To understand the transcriptional consequences of Progeria LmnaG609G mutation within the immune compartment of the lung we conducted single cell RNA sequencing on sorted immune cells from WT vs. LmnaG609G/G609G mice (in duplicate, 2 mice per group).
ORGANISM(S): Mus musculus 
2024-08-01 | GSE183249 | GEO
TranscriptomicsTranscriptional profiling of liver samples from Lmna Gly609Gly knock-in mice
Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by a point mutation in the LMNA gene that activates a cryptic donor splice site and yields a truncated form of prelamin A called progerin. Small amounts of progerin are also produced during normal aging. Studies with mouse models of HGPS have all...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-32609 | biostudies-arrayexpress
UnknownPremature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson-Gilford Progeria Syndrome with Ldlr Deficiency.
Not available
S-EPMC7601818 | biostudies-literature
UnknownAnti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice.
Not available
S-EPMC9811625 | biostudies-literature
UnknownNormal Bone Matrix Mineralization but Altered Growth Plate Morphology in the Lmna<sup>G609G/G609G</sup> Mouse Model of Progeria.
Not available
S-EPMC12339082 | biostudies-literature
UnknownVascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.
Not available
S-EPMC6075893 | biostudies-literature
GenomicsUnderstanding the transcriptional consequences of the Progeria LmnaG609G mutation within the immune compartment of the lung using single cell RNA sequencing.
Understanding the transcriptional consequences of the Progeria LmnaG609G mutation within the immune compartment of the lung using single cell RNA sequencing.
PRJNA759785 | ENA
GenomicsBulk RNA-seq of multiple organs in LmnaG609G progeria mice with inducible Δ133p53α
Bulk RNA-seq of multiple organs in LmnaG609G progeria mice with inducible Δ133p53α
PRJNA1395132 | ENA
Sort   by:  
 Page size