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ProteomicsThe mass spectrometry (MS) to screen for Flag-tagged S100A6 binding
To identify potential regulatory factors associated with S100A6 during HGPS senescence, we used mass spectrometry (MS) to screen for S100A6 binding proteins. PARP1, RPL6, TCP1, CAD, XPO1 and RPS18 were identified as S100A6-binding proteins by MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD061708 | Pride
Human Flag-s100a6，mass spectrometry analysis 
TranscriptomicsThe mechanism of elevated S100A6 (Calcyclin) Enhances Tumorigenesis in clear cell renal cell carcinoma
Among all types of urological cancers, the clear cell renal cell carcinoma is the second leading cause of death in adults. This is mainly due to lack of promising prognosis or predictors, and effective target therapy. S100A6 (calcyclin), a member of S100 family of proteins, is reported to be elevate...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-GEOD-52708 | biostudies-arrayexpress
ProteomicsRegulatory Role of S100A6 in Hematopoetic Stem Cells
The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration and apoptosis, but the interaction between intracellular Ca2+ and cytoplasmic chaperon protein in regulating fate options of long term-HSCs (LT-HSC) is unknown. We created a S100A6 conditional knocko...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-22 | PXD015854 | Pride
Mouse Hematopoetic stem cell Lc-ms/ms 
GenomicsS100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kb/VEGF-D pathway
S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kb/VEGF-D pathway
PRJNA1051007 | ENA
TranscriptomicsThe mechanism of elevated S100A6 (Calcyclin) Enhances Tumorigenesis in clear cell renal cell carcinoma
Among all types of urological cancers, the clear cell renal cell carcinoma is the second leading cause of death in adults. This is mainly due to lack of promising prognosis or predictors, and effective target therapy. S100A6 (calcyclin), a member of S100 family of proteins, is reported to be elevate...
ORGANISM(S): Homo sapiens 
2013-11-25 | GSE52708 | GEO
TranscriptomicsS100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling
S100A6, a member of the S100 protein family, has been described as relevant for cell cycle entry and progression in endothelial cells. The molecular mechanism conferring S100A6's proliferative actions, however, remained elusive. Originating from the clinically relevant observation of enhanced S100A6...
ORGANISM(S): Homo sapiens 
2016-11-21 | GSE69380 | GEO
TranscriptomicsS100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kb/VEGF-D pathway
Patients diagnosed with lymph node (LN) metastatic liver cancer face an exceedingly grim prognosis. In-depth analysis of LN metastatic patients’ characteristics and tumor cells’ interactions with human lymphatic endothelial cells (HLECs), can provide important biological and therapeutic insights. He...
ORGANISM(S): Homo sapiens 
2025-10-07 | GSE249843 | GEO
ProteomicsQuantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Maternal serum levels of calcyclin and heat shock protein 90 were compared throughout pregnancy from the first trimester till term among women with preeclampsia (PE) and age-matched normotensive pregnant controls (C). Serum samples from two different studies, a nested case-control study embedded in ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD009025 | Pride
Hsp90 S100a6 Prm Serum Preeclampsia Placenta 
UnknownAstrocytes modulate neuronal development by S100A6 signaling.
Not available
S-EPMC12518605 | biostudies-literature
UnknownBinding of S100A6 to actin and the actin-tropomyosin complex.
Not available
S-EPMC7393103 | biostudies-literature
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