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TranscriptomicsTranscription profiling of spinal cords from nmd mice tranplanted with ALDHhiSSClo neural stem cells to study molecular mechanism of delayed SMARD1 disease progression induced by the transplantation.
SMARD1 is an infantile autosomal recessive motor neuron (MN) disease, caused by mutations in the Immunoglobulin mu binding protein 2 (IGHMBP2). We investigated the potential of a spinal cord neural stem cell population isolated on the basis of aldehyde dehydrogenase activity (ALDH) to modify disease...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3075 | biostudies-arrayexpress
ProteomicsGreatwall kinase controls cell cycle progression in AML cells independently of PP2A-B55-ENSA
MASTL kinase canonically regulates mitotic progression through the phosphorylation of ENSA and ARPP19, leading to the inhibition of PP2A-B55 phosphatase. Through its role in cell cycle regulation, MASTL is involved in oncogenesis in solid tumours. However, whether MASTL has a role in haematological ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-25 | PXD068482 | Pride
Aml Mastl Mitosis Cell cycle Phosphoproteomics 
TranscriptomicsLaser Capture Microdissection of Hyperlipidemic Mouse Aorta Atherosclerosis
Atherosclerosis is a transmural chronic inflammatory condition of small and large arteries that is associated with adaptive immune responses at all disease stages. However, impacts of adaptive immune reactions on clinically apparent atherosclerosis such as intima lesion (plaque) rupture, thrombosis,...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-21419 | biostudies-arrayexpress
ProteomicsDecoding the phosphoproteomic signature of hallucinogenic psychedelics
How psychedelic drugs generate altered states of consciousness while promoting enduring neuroplasticity remains a fundamental question in neuroscience with therapeutic implications. Here, we used quantitative phosphoproteomics in neural cultures to map intracellular signaling responses to serotonerg...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-25 | PXD070037 | Pride
Psychedelics Signalling Kinase Phosphoproteomics 
ProteomicsMaternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells
To undertake a comprehensive examination of the molecular mechanisms governing the alterations induced by maternal immune activation (MIA) during gestation that impacts the subsequent neurodevelopment of progeny, we have devised an in vitro model based on neural stem cells (NSCs) sourced from fetuse...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-16 | PXD056291 | Pride
Phosphoproteomics Neuron Neural stem cells Development Proteomics Maternal immune activation 
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
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