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Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071609 | Pride
Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071657 | Pride
The NRF2 transcription factor is constitutively active in cancer where it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2-dependency and resistance to chemo/radiotherapy. Here we characterize VVD-065, a first-in-class NRF2 inhibitor that...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071555 | Pride
Assessment of VVD-065 protein selectivity via protein enrichment with VVD-369, an alkylated version of VVD-065.
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071607 | Pride
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