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ProteomicsChemoproteomic analysis of VVD-065 Protein Selectivity
Assessment of VVD-065 protein selectivity via protein enrichment with VVD-369, an alkylated version of VVD-065.
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071607 | Pride
Vvd-065 Keap1 Vvd-369 
ProteomicsChemoproteomic Profiling of VVD-065 Selectivity
The NRF2 transcription factor is constitutively active in cancer where it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2-dependency and resistance to chemo/radiotherapy. Here we characterize VVD-065, a first-in-class NRF2 inhibitor that...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071555 | Pride
Nrf2 Keap1 Vvd-065 
ProteomicsChemoproteomic Cysteine Selectivity of VVD-065, VVD-330 and VVD-325
Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071657 | Pride
Nrf2 Keap1 Vvd-330 Vvd-065 Vvd-325 
TranscriptomicsSuppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue
The NRF2 transcription factor is constitutively active in cancer where it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2-dependency and resistance to chemo/radiotherapy. Here we developed VVD-065, a first-in-class NRF2 inhibitor that ac...
ORGANISM(S): Homo sapiens 
2025-01-03 | GSE278482 | GEO
GenomicsSuppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue
Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue
PRJNA1167342 | ENA
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