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TranscriptomicsTranscription profiling of human monocytes reveals leukotriene D4 induces gene expression through cysteinyl leukotriene type I receptor.
Background: Cysteinyl leukotrienes (cysLTs) are important mediators of innate immune responsiveness and chronic inflammatory diseases. CysLTs acting through cysteinyl leukotriene receptors may influence the migration and activity of cells such as eosinophils, monocytes and dendritic cells. Objective...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7807 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells, or whole blood were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge vs controls
Peripheral blood mononuclear cells were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge using cell preparation tubes (Vacutainer® CPT). The PBMC layer was lysed with RLT buffer, homogenized, and then stored at –80°C. Total RNA was extracted as per RNeasy‚ Midi protocol...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-3026 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with interferon gamma and/or dexamethasone
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1815 | biostudies-arrayexpress
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells
This SuperSeries is composed of the following subset Series: GSE39059: Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [mRNA] GSE39060: Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [miRNA] Refer to i...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39061 | biostudies-arrayexpress
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [mRNA]
Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vit...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39059 | biostudies-arrayexpress
TranscriptomicsChanges in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [miRNA]
Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vit...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-39060 | biostudies-arrayexpress
TranscriptomicsHIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue
Exploratory microarray analysis identified significant changes in gene expression in adipose tissue. These included changes in genes regulating lipid and steroid metabolic processes and electron carrier activity in HIV-infected patients receiving antiretroviral therapy (ART). Additional genes invo...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-30310 | biostudies-arrayexpress
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