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TranscriptomicsPBMC response to B. pertussis filamentous hemagglutinin stimulation in vitro
Filamentous hemagglutinin (FHA), Bordetella pertussis' key adhesin, is both present at the cell surface and released in the extracellular milieu. To comprehend the role free FHA plays in the pathogenic process, we analyzed the global transcriptional changes in human peripheral blood mononuclear cell...
ORGANISM(S): Homo sapiens 
2008-10-29 | E-GEOD-8802 | biostudies-arrayexpress
TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia II.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76739 | biostudies-arrayexpress
TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76743 | biostudies-arrayexpress
TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia I.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76741 | biostudies-arrayexpress
ProteomicsProteomic profiling of Palbociclib arrested cells ± APC/C inactivation.
Cellular proliferation is highly regulated to ensure proper tissue homeostasis and to prevent diseases such as cancer. In actively proliferating cells, entry into S phase of the cell cycle and initiation of DNA replication is promoted by inactivation of the E3 ubiquitin ligase APC/C (anaphase promot...
ORGANISM(S): Homo sapiens (Human) 
2024-07-18 | PXD046783 | Pride
Cancer Palbociclib Cell cycle Apc/c 
ProteomicsThe Escherichia coli RelB antitoxin C-terminus is essential for RelE toxin suppression and transcriptional repression.
Bacterial type II toxin-antitoxin (TA) systems exhibit high specificity within each pair to ensure precise recognition of the toxin by its cognate antitoxin to inhibit toxicity of the free toxin. Despite high structural similarity among some TAs, crosstalk between noncognate TA pairs is rare. To det...
ORGANISM(S): Escherichia coli 
2025-07-06 | PXD065338 | Pride
Relb E coli Antitoxin 
TranscriptomicsBAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
Previous data have suggested that B-cell–depletion therapy may induce the settlement of autoreactive long-lived plasma cells (LLPCs) in the spleen of patients with autoimmune cytopenia. To investigate this process, we used the AID-CreERT2-EYFP mouse model to follow PCs engaged in an immune response....
ORGANISM(S): Mus musculus 
2018-02-19 | E-MTAB-6449 | biostudies-arrayexpress
TranscriptomicsResponse of Rhodopirellula baltica to heat shock
Expression profiling of the stress response of the marine Planctomycete Rhodopirellula baltica after a temperature up-shift. R. baltica cultures were grown at 28°C and then shifted to 37°C. Samples were taken after 10, 20, 40, 60 and 300min and compared with cultures before the up-shift (28°C). Tim...
ORGANISM(S): Rhodopirellula baltica 
2009-09-09 | E-GEOD-13769 | biostudies-arrayexpress
TranscriptomicsResponse of Rhodopirellula baltica to cold shock
Expression profiling of the stress response of the marine Planctomycete Rhodopirellula baltica after a temperature up-shift. R. baltica cultures were grown at 28°C and then shifted to 6°C. Samples were taken after 10, 20, 40, 60 and 300min and compared with cultures before the up-shift (28°C). Re...
ORGANISM(S): Rhodopirellula baltica 
2009-09-09 | E-GEOD-13856 | biostudies-arrayexpress
ProteomicsNovel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing.
Single cell sequencing in peripheral blood mononuclear cells (PBMCs) revealed a novel human-specific long noncoding RNA called heart-failure associated transcript 4 (HEAT4). HEAT4 expression was assessed in several in vitro and ex vivo models of immune cell activation, as well as in the blood of pat...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD052076 | Pride
Monocytes Long non-coding rna Heart failure Vascular regeneration 
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