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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
UnknownLong-Term Outcomes in Patients With BRAF V600-Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib.
Not available
S-EPMC10466457 | biostudies-literature
TranscriptomicsA Smooth Muscle-Like Origin for Beige Adipocytes
A comparison of the translating RNAs in UCP1-positive cells from the classical BAT, the inguinal WAT, and the perigonadal WAT. We find genes common to all UCP1-positive cells independent of anatomical location, as well as genes specifically enriched in one group versus the others. Results provide a ...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56248 | biostudies-arrayexpress
UnknownThe long non-coding RNA SAMMSON is essential for uveal melanoma cell survival.
Not available
S-EPMC8724009 | biostudies-literature
ProteomicsProteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin
Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.
ORGANISM(S): Mycobacterium Smegmatis Str. Mc2 155 (ncbitaxon:246196) 
2019-03-18 | MSV000083589 | MassIVE
ProteomicsOrganism-wide secretome mapping of tissue crosstalk in exercise
Physical activity is a powerful physiologic stimulus that provides benefits to multiple organ systems and confers protection against disease. These physiologic effects are in part mediated by blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD034535 | Pride
Plasma Proteomics In vivo Exercise Secreteome Mice 
MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
UnknownRole of the β<sub>2</sub>-adrenergic receptor in podocyte injury and recovery.
Not available
S-EPMC11126448 | biostudies-literature
ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
TranscriptomicsTranscription profiling time series of leaves from winter wheat grown under S and N-deficient conditions
Transcripomic analysis of leaf gene expression in S and N-deficient winter wheat during grain development. Tissue was harvested at anthesis and 7, 14 and 21 days post anthesis from experimental field plots.
ORGANISM(S): Triticum aestivum 
2008-09-18 | E-MEXP-1415 | biostudies-arrayexpress
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