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ProteomicsHuman cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation
Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and modulating their activities. We investigated the role of RNA1.2...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) 
2020-07-08 | PXD018328 | Pride
Tprg1l Il-6 Gene regulation Nf-κb Lncrna Transcriptomics Human cytomegalovirus 
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
ProteomicsViral lncRNA upregulates multiple A+U-richViral lncRNA upregulates multiple A+U-rich transcripts to promote cell motility and viral dissemination transcripts to promote cell motility and viral dissemination
Long non-coding RNAs are frequently associated with broad modulation of gene expression and thus provide the cell with the ability to synchronize entire metabolic processes. We used transcriptomic and proteomic approaches to investigate whether the most abundant human cytomegalovirus-encoded lncRNA,...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) 
2021-07-27 | PXD022277 | Pride
Cell motility Gene regulation Lncrna A+u rich Transcriptomics Human cytomegalovirus Viral dissemination 
TranscriptomicsHolo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
TFIID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID is more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and d...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-45873 | biostudies-arrayexpress
TranscriptomicsHost gene expression profiling on children with any cause critical illness at retrieval or admission to paediatric critical care
We analysed data collected as part of the Biomarkers of Acute Serious Illness in Children (BASIC) study. BASIC was a prospective cohort study that enrolled critically ill children admitted to four PICUs in London and Eastern England, UK, during emergency transport by the Children’s Acute Transport S...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15164 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine macrophage-like RAW 264.7 cells treated with EdTx, protective antigen, or LPS for different length of time to examine the effect of EdTx on global transcriptional profiles.
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstiti...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4712 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes
Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this d...
ORGANISM(S): Homo sapiens 
2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
UnknownKey role for myeloid cells: phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma.
Not available
S-EPMC4292931 | biostudies-literature
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