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TranscriptomicsExpression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine
L-Arginine (L-Arg) is the substrate for both inducible nitric oxide synthase and arginase, which are upregulated in human IBD and in mouse colitis models. We have found that L-Arg supplementation enhances wound restitution in vitro, and improves the clinical parameters of weight loss, survival, and ...
ORGANISM(S): Mus musculus 
2012-06-26 | E-GEOD-34874 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of e15.5 pancreas from Wild Type, Blinc1-/- and Blinc+/- mice.
We report the transcriptome changes that result of the genomic deletion of one or two alleles of an islet-specific long non-coding RNA (Blinc1) in isolated pancreas from e15.5 mouse embryos. Pancreas from e15.5 embryos were dissected and total RNA extracted. Libraries were prepared from total RNA (R...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-73711 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Nkx2.2 mutant embryos at E12.5 and E13.5 to identify a transcripional program that Nkx2.2 regulation in the pancreas
The goal of this experiment was to analyze expression changes in the pancreas at embryonic days 12.5 and 13.5 between wild type and Nkx2.2 null mice. We know that Nkx2.2 is essential for pancreatic endocrine differentiation and development. At these early time points which are critical for endocri...
ORGANISM(S): Mus musculus 
2009-11-05 | E-CBIL-44 | biostudies-arrayexpress
TranscriptomicsGene expression alteration by macrophage depletion in IKKα mutant mice
We generated Ikkα-KA/KA knock-in mice (KA/KA), in which an ATP binding site of Ikkα Lys 44 was replaced by alanine. The knock-in mice develop severe skin lesions and begin to die after 6 to 10 months. We also found lung SCCs in some of the mice. To study lung SCC development, we stabilize the skin c...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-37655 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FNR transcriptional regulator and NarP response regulator knock-out strains of Neisseria gonorrhoeae
Knock out mutants of FNR transcriptional regulator (NGO1579) and NarP response regulator (NGO0752) in N. gonorrhoeae compared to parent strain grown in liquid culture.
ORGANISM(S): Neisseria gonorrhoeae 
2006-08-15 | E-MEXP-726 | biostudies-arrayexpress
UnknownSeeing slavery in seafood supply chains.
Not available
S-EPMC6059758 | biostudies-literature
ProteomicsThe histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux
Epigenetic regulation and metabolism are connected. Epigenetic regulators, like the SIN3 complex, affect the expression of a wide range of genes, including those encoding metabolic enzymes essential for central carbon metabolism. The idea that epigenetic modifiers can sense and respond to metabolic ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-10-14 | PXD058616 | Pride
Histone modification Respiration Gene regulation Energy metabolism Drosophila 
TranscriptomicsTranscription profiling of normal mouse lung from age matched untreated controls from AJ mice were from two time points 24 to 26 weeks (N) or 42 weeks (N42) after saline injection
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis to identify a unique macrophage expression signature in the lung tumor microenvironment. Experiment Overall Design: RNA from lung tissu...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7244 | biostudies-arrayexpress
UnknownCD4 promoter transactivation by human herpesvirus 6.
Not available
S-EPMC110296 | biostudies-literature
UnknownRisk Assessment of Transgender People: Development of Rodent Models Mimicking Gender-Affirming Hormone Therapies and Identification of Sex-Dimorphic Liver Genes as Novel Biomarkers of Sex Transition
Not available
S-EPMC9913858 | biostudies-literature
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