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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
TranscriptomicsGenome-wide transcriptional analysis of PE-2 strain of Saccharomyces cerevisiae
In this study we investigate the molecular physiology of the main S. cerevisiae commercial strain (PE-2) used on Brazilian bioethanol process under two distinct conditions: typical (TF) and flocculated (co-aggregated - FL) fermentation. Transcriptional machinery of PE-2 was assessed by high throughp...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-02 | E-GEOD-41834 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiomyocytes (NRVCMs) stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM
Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5996 | biostudies-arrayexpress
TranscriptomicsGlobal Transcriptional Analysis of Spontaneous Sakacin P-Resistant Mutant Strains of Listeria monocytogenes during Growth on Different Sugars
Subclass IIa bacteriocins have strong antilisterial activity and can control the growth of Listeria monocytogenes in food. However, L. monocytogenes may develop resistance towards such bacteriocins. In this follow-up study, the transcriptomes of a high level (L502-1) and a low level (L502-6) spontan...
ORGANISM(S): Listeria monocytogenes 
2011-04-15 | E-BUGS-110 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis using a transposon mutagenesis approach to elucidate pe/ppe regulation
Data is also available from BuG@Sbase
ORGANISM(S): Mycobacterium tuberculosis 
2009-08-18 | E-BUGS-91 | biostudies-arrayexpress
TranscriptomicsGlobal spatial organization of M-NM-3 proteobacterial nucleoids is determined by specific long-range interactions (E. coli)
GCC was used to determine the structure of E. coli grown in LB or treated with SHX. The bacterial genome is highly condensed into a nucleoid structure. Here we present global analyses of the genome spatial organization for two M-NM-3-proteobacteria: Escherichia coli and Pseudomonas aeruginosa by Ge...
ORGANISM(S): Escherichia coli 
2013-05-02 | E-GEOD-40603 | biostudies-arrayexpress
TranscriptomicsSynergism between PPAR? and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [RNA-seq]
Analyses of gene expression by RNA-Seq in mouse E14.5 fetal liver burst-forming unit erythroid (BFU-E) cells untreated or treated by dexamethasone (DEX) with or without PPAR? agonist GW7647. RNA-Seq was performed on enriched populations of mouse BFU-E isolated from E14.5 fetal liver, as well as BFU-...
ORGANISM(S): Mus musculus 
2015-06-08 | E-GEOD-63836 | biostudies-arrayexpress
TranscriptomicsShort and Long RNA sequencing of human mature erythrocytes
We employed high-throughput sequencing of both short (~18-24nt) and long (>200nt) RNAs in human erythrocytes. We obtained blood from five healthy individuals for the short (small) RNA-seq library preparations and blood from three individuals for the long RNA-seq library preparations. We identified a...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-63703 | biostudies-arrayexpress
TranscriptomicsEffect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts on Longissimus thoracis transcriptome in growing-finishing Italian Large White pigs
Background: Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat products. Diet composition has been also demonstrated to influence the gene expression with effect on biological processes and pathways. However, the knowledge on the effect of nutrien...
ORGANISM(S): Sus scrofa 
2019-06-29 | E-MTAB-7131 | biostudies-arrayexpress
TranscriptomicsEffect of long-term high CO2 environment on gene expression of Phaeodactylum tricornutum
P. tricornutum (Bacillariophyta, Pennatae, NEPCC640) was obtained from the Algal Center of the Institute of Oceanology of the Chinese Academy of Sciences. The cells were cultured in a modified f/2 medium (Guillard, 1975) at 20 +/- 1C, and illuminated with 120 umol photon m-2 s-1 under a 12:12 light:...
ORGANISM(S): Phaeodactylum tricornutum 
2019-11-07 | E-MTAB-8351 | biostudies-arrayexpress
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