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UnknownAssociation between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database.
Not available
S-EPMC10230925 | biostudies-literature
TranscriptomicsGene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regula...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
Transcriptomics16S rRNA gene sequence analysis of feces samples from rats treated with paclitaxel or vehicle controls
To address the role of gut microbiota in the development of paclitaxel-induced peripheral neuropathy (PIPN), we performed 16S rRNA sequencing analysis of feces samples at 14 days and 28 days after the initiation of paclitaxel or vehicle injections.
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13426 | biostudies-arrayexpress
MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
ProteomicsProteomic study on the reproductive toxicity of Tripterygium glycosides in rats
Tripterygium glycoside tablet (TGT) is a common clinically used and effective non-steroidal immunosuppressant. However, its reproductive toxicity limits its application in pediatric immune diseases, warranting the study of the molecular mechanism behind its reproductive toxicity. In the present stud...
ORGANISM(S): Rattus Rattus 
2022-03-02 | PXD031978 |
Transcriptomics16S rRNA gene sequence analysis of feces samples from 60 breast cancer patients treated with paclitaxel and 20 healthy controls
We randomly selected 60 patients who completed paclitaxel treatment for high-throughput sequencing. Grade 2 or higher (grade 2+) neuropathy has been defined as high-PIPN and Grade 1 as low-PIPN according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI-CTCAE version ...
ORGANISM(S): Homo sapiens 
2023-10-12 | E-MTAB-13423 | biostudies-arrayexpress
ProteomicsZmbZIP39 coordinates source-flow-sink relations to boost grain filling in maize
The orchestration of source, flow, and sink is fundamental to efficient grain filling in maize, yet the regulatory network synchronizing these processes remains a major enigma. To identify key regulators, we used the sucrose transporter ZmSUT1, a critical component of the ‘flow’ pathway, as a molecu...
ORGANISM(S): Zea Mays 
2025-10-24 | PXD069873 |
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
GenomicsGonadal DNA methylomes of half-smooth tongue sole Cynoglossus semilaevis
Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa, and in some species co-occurs with genetic sex determination (GSD) mechanisms. Although epigenetic regulation in response to environmental effects has long been proposed to be associated with ESD, a systemic ...
ORGANISM(S): Cynoglossus semilaevis 
2014-01-23 | E-GEOD-41129 | biostudies-arrayexpress
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